PET imaging of reactive astrocytes in neurological disorders

被引：0
作者：
Yu Liu
Han Jiang
Xiyi Qin
Mei Tian
Hong Zhang
机构：
[1] The Second Affiliated Hospital of Zhejiang University School of Medicine,Department of Nuclear Medicine and PET Center
[2] Institute of Nuclear Medicine and Molecular Imaging of Zhejiang University,PET
[3] Key Laboratory of Medical Molecular Imaging of Zhejiang Province,CT Center
[4] Fujian Medical University Union Hospital,College of Biomedical Engineering & Instrument Science
[5] Zhejiang University,Key Laboratory for Biomedical Engineering of Ministry of Education
[6] Zhejiang University,undefined
来源：
European Journal of Nuclear Medicine and Molecular Imaging | 2022年 / 49卷
关键词：
Positron emission tomography (PET); Reactive astrocytes; Monoamine oxidases-B (MAO-B); Alzheimer’s disease (AD); Parkinson’s disease (PD); Amyotrophic lateral sclerosis (ALS); Multiple sclerosis (MS);
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The reactive astrocytes manifest molecular, structural, and functional remodeling in injury, infection, or diseases of the CNS, which play a critical role in the pathological mechanism of neurological diseases. A growing need exists for dependable approach to better characterize the activation of astrocyte in vivo. As an advanced molecular imaging technology, positron emission tomography (PET) has the potential for visualizing biological activities at the cellular levels. In the review, we summarized the PET visualization strategies for reactive astrocytes and discussed the applications of astrocyte PET imaging in neurological diseases. Future studies are needed to pay more attention to the development of specific imaging agents for astrocytes and further improve our exploration of reactive astrocytes in various diseases.
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页码：1275 / 1287
页数：12
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