Structural basis for the recruitment of the human CCR4–NOT deadenylase complex by tristetraprolin

被引：0
作者：
Marc R Fabian
Filipp Frank
Christopher Rouya
Nadeem Siddiqui
Wi S Lai
Alexey Karetnikov
Perry J Blackshear
Bhushan Nagar
Nahum Sonenberg
机构：
[1] Lady Davis Institute for Medical Research,Department of Oncology
[2] Jewish General Hospital,Department of Biochemistry
[3] McGill University,undefined
[4] McGill University,undefined
[5] Goodman Cancer Centre,undefined
[6] McGill University,undefined
[7] Laboratory of Signal Transduction,undefined
[8] National Institute of Environmental Health Science,undefined
来源：
Nature Structural & Molecular Biology | 2013年 / 20卷
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摘要：
Tristetraprolin (TTP) post-transcriptionally represses gene expression by interacting with AU-rich elements in 3A untranslated regions of target mRNAs and mediates deadenylation and decay by recruiting the CCR4–NOT deadenylase complex through the CNOT1 subunit. Structural and mutational studies now show how the TTP-CNOT1 interaction brings about TTP-mediated deadenylation of target mRNAs.
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页码：735 / 739
页数：4
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