Serum Apelin Levels and Ascending Aortic Aneurysm in Adults

被引:0
作者
Mihriban Yalcin
Gündüz Yumun
Ahsen Yilmaz
Hakan Kalafat
Savaş Guzel
机构
[1] Ordu State Hospital,Cardiovascular Surgery
[2] Namık Kemal University,Cardiovascular Surgery
[3] Namık Kemal University,Medical Biochemistry
[4] Ordu State Hospital,Medical Biochemistry
来源
Indian Journal of Surgery | 2021年 / 83卷
关键词
Adult; Ascending aortic aneurysm; Apelin; Apelin receptor;
D O I
暂无
中图分类号
学科分类号
摘要
Apelin is a peptide isolated from bovine stomach and has vasodilator and inotropic activities. The aim of this study was to confirm the relationship between serum apelin levels and ascending aortic dilatation in adult patients. This study included 39 patients with ascending aortic aneurysm who applied to the cardiovascular surgery outpatient clinic between 1 June 2019 and 31 August 2019 and 50 healthy volunteers. Serum apelin and serum apelin receptor levels were measured with ELISA method. Serum apelin levels were lower in patients with aortic aneurysm compared to the control group, while serum apelin receptor levels were higher. These findings may show that serum apelin and apelin receptor levels may be a potential biomarker for aortic aneurysm.
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页码:881 / 884
页数:3
相关论文
共 75 条
  • [1] Cheng B(2012)Neuroprotection of apelin and its signaling pathway Peptides 37 171-173
  • [2] Chen J(2013)Regulation of feeding behavior, gastrointestinal function and fluid homeostasis by apelin Peptides 44 87-92
  • [3] Bai B(2013)Apelin and APJ, a novel critical factor and therapeutic target for atherosclerosis Acta Biochim Biophys Sin Shanghai 45 527-533
  • [4] Xin Q(2010)Translational promise of the apelin–APJ system Heart 96 1011-1016
  • [5] Lv SY(2001)The novel peptide apelin lowers blood pressure via a nitric oxide-dependent mechanism Regul Pept 99 87-92
  • [6] Yang YJ(2013)Masked hypertension and atherogenesis: the impact of apelin and relaxin plasma levels J Clin Hypertens (Greenwich) 15 333-336
  • [7] Chen Q(2011)Disruption of the apelin–APJ system worsens hypoxia-induced pulmonary hypertension Arterioscler Thromb Vasc Biol 31 814-820
  • [8] Lv D(2014)Apelin and its receptor APJ in cardiovascular diseases Clin Chim Acta 428 1-8
  • [9] Li H(2016)The genetics and pathogenesis of thoracic aorticaneurysm disorder and dissections Clin Genet 89 639-646
  • [10] Chen L(2008)Reduced apelin levels in stable angina Intern Med 47 1951-1955