Selective association of endogenous ouabain with subclinical organ damage in treated hypertensive patients

被引：0
作者：
G Nagy
B Gaszner
É Lányi
L Markó
E Fehér
J Cseh
T Kõszegi
J Betlehem
E Sulyok
A Cziráki
I Wittmann
机构：
[1] Faculty of Medicine,2nd Department of Medicine and Nephrological Center
[2] University of Pécs,Department of Laboratory Medicine
[3] Faculty of Medicine,Department of Radiology
[4] Heart Institute,Department of Emergency Care
[5] University of Pécs,undefined
[6] Faculty of Medicine,undefined
[7] University of Pécs,undefined
[8] Faculty of Medicine,undefined
[9] University of Pécs,undefined
[10] Faculty of Health Sciences,undefined
[11] University of Pécs,undefined
[12] Faculty of Health Sciences,undefined
[13] University of Pécs,undefined
来源：
Journal of Human Hypertension | 2011年 / 25卷
关键词：
endogenous ouabain; nighttime blood pressure; arterial stiffness; subclinical organ damage;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
According to previous studies endogenous ouabain (EO) closely correlates with high blood pressure, congestive heart failure and kidney disease in humans. Our aims were to analyse associations between plasma, urinary EO level and various markers of cardiovascular damage in treated hypertensive patients. Forty-one adult patients with hypertension and/or diabetes mellitus (DM) and/or chronic kidney disease (CKD) were studied. We assessed plasma and urinary EO, pro-brain natriuretic peptide and catecholamines, profile of ambulatory blood pressure monitor and cardiovascular status by echocardiography and echo-tracking. The highest level of plasma EO (19.7±9.5 pmol l–1) was measured in hypertensive patients with DM and CKD. The nighttime mean arterial blood pressure independently correlated with the level of plasma EO (P=0.004), while independent predictor of the β-stiffness of carotid artery was the urinary EO (P=0.011). Elevated level of EO was associated with nighttime blood pressure and subclinical organ damage in treated hypertensive patients, suggesting possible role of EO in the pathogenesis of impaired diurnal blood pressure rhythm and arterial stiffness.
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页码：122 / 129
页数：7
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共 185 条
  • [1] Hamlyn JM(1991)Identification and characterization of an ouabain-like compound from human plasma Proc Natl Acad Sci USA 88 6259-6263
  • [2] Blaustein MP(2008)Endogenous digitalis: pathophysiologic roles and therapeutic applications Nat Clin Pract Nephrol 4 378-392
  • [3] Bova S(2009)Endogenous ouabain in cardiovascular function and disease J Hypertens 27 9-18
  • [4] DuCharme DW(2008)Endogenous ouabain and cardiomyopathy in dialysis patients J Intern Med 263 274-280
  • [5] Harris DW(2005)Ouabain-like compound changes rapidly on physical exercise in humans and dogs: effects of ß-blockade and angiotensin-converting enzyme inhibition Hypertension 45 1024-1028
  • [6] Mandel F(1991)Antidigoxin antibodies neutralize the effect of newborn endogenous digitalis-like factor on erythrocyte 86Rb uptake J Nucl Biol Med 35 38-40
  • [7] Bagrov AY(2009)Endogenous cardiotonic steroids: physiology, pharmacology, and novel therapeutic targets Pharmacol Rev 61 9-38
  • [8] Shapiro JI(2009)The pump, the exchanger, and endogenous ouabain: signaling mechanisms that link salt retention to hypertension Hypertension 53 291-298
  • [9] Manunta P(2006)Physiological role of the alpha1- and alpha2-isoforms of the Na+-K+-ATPase and biological significance of their cardiac glycoside binding site Am J Physiol Regul Integr Comp Physiol 290 R524-R528
  • [10] Ferrandi M(1994)Chronic central versus peripheral ouabain, blood pressure, and sympathetic activity in rats Hypertension 23 1087-1090
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