Effect of nitroderivatives of fullerene C60 on amyloid fibrils of the brain Aβ(1-42) peptide and muscle X-protein

被引：5

作者：

Bobylev A.G. ^{[1
]}

Marsagishvili L.G. ^{[1
]}

Shpagina M.D. ^{[1
]}

Romanova V.S. ^{[2
]}

Kotelnikova R.A. ^{[3
]}

Podlubnaya Z.A. ^{[1
,4
]}

机构：

[1] Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino

[2] Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences

[3] Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka

[4] Pushchino State University, Pushchino

来源：

Biophysics | 2010年 / 55卷 / 3期

基金：

俄罗斯基础研究基金会;

关键词：

Aβ; peptides; Alzheimer's disease; amyloidoses; amyloids; fullerenes; muscle X-protein;

D O I：

10.1134/S0006350910030024

中图分类号：

学科分类号：

摘要：

The antiamyloidogenic capacity of water-soluble nitroderivatives of fullerene C60: methyl ester of L-N-[(2-nitroglyceryl) fullerenyl] proline, methyl ester of L-N-[(2,3-dinitroglyceryl) fullerenyl] proline, and 2-nitroxyethyl ester of L-N-([2-(nitroxy) ethyl] fullerenyl) proline has been studied in vitro by high-resolution electron microscopy. It was shown that these fullerene C60 nitroderivatives are able to prevent the formation of amyloid fibrils by the brain Aβ(1-42)-peptide and muscle X-protein and to destroy mature fibrils. Electron microscopy is a promising method for selecting effective antiamyloidogenic drugs. The antiamyloidogenic activity of nanodimensional fullerene C60 nitroderivatives offers strong possibilities for creating a new nanotechnology for the therapy of amyloidoses. © 2010 Pleiades Publishing, Ltd.

引用

页码：353 / 357

页数：4

共 14 条

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