Risk of death does not alter the efficacy of hydrocortisone therapy in a mouse E. coli pneumonia model Risk and corticosteroids in sepsis

[1] Knaus WA(1996)Use of predicted mortality to evaluate the efficacy of anti-cytokine therapy in sepsis: the IL-1ra Phase III Sepsis Syndrome Study Group Crit Care Med 24 46-56

[2] Harrell FE(2004)Efficacy and safety of the monoclonal anti-tumor necrosis factor F(ab')2 fragment afelimomab in patients with severe sepsis and elevated interleukin-6 levels Crit Care Med 32 2173-2182

[3] LaBrecque JF(2002)Risk and efficacy of anti-inflammatory agents: retrospective and confirmatory studies of sepsis Am J Respir Crit Care Med 166 1197-1205

[4] Wagner DP(2004)Severity of sepsis alters the effects of superoxide anion inhibition in a rat sepsis model J Appl Physiol 97 1349-1357

[5] Pribble JP(2001)Efficacy and safety of recombinant activated protein C for severe sepsis N Engl J Med 344 699-709

[6] Draper EA(2004)Meta-analysis: the effect of steroids on survival and shock during sepsis depended on dose Ann Intern Med 141 47-56

[7] Fisher CJ(1998)Reversal of late septic shock with supraphysiologic dose hydrocortisone Crit Care Med 26 645-650

[8] Soll L(2002)Physiological-dose steroid therapy in sepsis [ISRCTN36253388] Crit Care 6 251-259

[9] Panacek EA(2002)Effect of treatment with low doses of corticosteroid and fludrocortisone on mortality in patients with septic shock JAMA 288 862-871

[10] Marshall JC(2005)Hydrocortisone infusion for severe community-acquired pneumonia. A preliminary randomized study Am J Respir Crit Care Med 171 242-248

[1] Knaus WA(1996)Use of predicted mortality to evaluate the efficacy of anti-cytokine therapy in sepsis: the IL-1ra Phase III Sepsis Syndrome Study Group Crit Care Med 24 46-56

[2] Harrell FE(2004)Efficacy and safety of the monoclonal anti-tumor necrosis factor F(ab')2 fragment afelimomab in patients with severe sepsis and elevated interleukin-6 levels Crit Care Med 32 2173-2182

[3] LaBrecque JF(2002)Risk and efficacy of anti-inflammatory agents: retrospective and confirmatory studies of sepsis Am J Respir Crit Care Med 166 1197-1205

[4] Wagner DP(2004)Severity of sepsis alters the effects of superoxide anion inhibition in a rat sepsis model J Appl Physiol 97 1349-1357

[5] Pribble JP(2001)Efficacy and safety of recombinant activated protein C for severe sepsis N Engl J Med 344 699-709

[6] Draper EA(2004)Meta-analysis: the effect of steroids on survival and shock during sepsis depended on dose Ann Intern Med 141 47-56

[7] Fisher CJ(1998)Reversal of late septic shock with supraphysiologic dose hydrocortisone Crit Care Med 26 645-650

[8] Soll L(2002)Physiological-dose steroid therapy in sepsis [ISRCTN36253388] Crit Care 6 251-259

[9] Panacek EA(2002)Effect of treatment with low doses of corticosteroid and fludrocortisone on mortality in patients with septic shock JAMA 288 862-871

[10] Marshall JC(2005)Hydrocortisone infusion for severe community-acquired pneumonia. A preliminary randomized study Am J Respir Crit Care Med 171 242-248