Preoperative Glucagon-like peptide-1 receptor imaging reduces surgical trauma and pancreatic tissue loss in insulinoma patients: A report of three cases

被引：10

作者：

Wenning A.S. ^{[1
]}

Kirchner P. ^{[2
]}

Antwi K. ^{[3
]}

Fani M. ^{[3
]}

Wild D. ^{[3
]}

Christ E. ^{[2
]}

Gloor B. ^{[1
]}

机构：

[1] University Hospital, Department of Visceral Surgery and Medicine, Inselspital, Berne

[2] University Hospital, Division of Endocrinology, Diabetology and Clinical Nutrition, Inselspital, Berne

[3] University Hospital, Department of Radiology, Division of Nuclear Medicine, Basel

来源：

Patient Safety in Surgery | / 9卷 / 1期

关键词：

Insulinoma; Superior Mesenteric Vein; Uncinate Process; Preoperative Localization; Pancreatic Tail;

D O I：

10.1186/s13037-015-0064-7

中图分类号：

学科分类号：

摘要：

Background: Insulinomas are rare tumors, in the majority of cases best treated by surgical resection. Preoperative localization of insulinoma is challenging. The more precise the preoperative localization the less invasive and safer is the resection. The purpose of the study is to check the impact of a new technique to localize insulinoma on the surgical strategy. Findings: We present exact preoperative localization with Glucagon-like peptide-1 receptor (GLP-1R) imaging. This allows a more precise resection thereby reducing surgical access trauma, loss of healthy pancreatic tissue and increasing safety and quality of the surgical intervention. Conclusion: With the help of precise preoperative localization of insulinoma with GLP-1R imaging the surgeon is able to minimize the amount of resected healthy pancreatic tissue. We hypothesize that GLP-1R imaging will become a preoperative diagnostic tool to be used for many patients scheduled for open or laparoscopic insulinoma resection. © 2015 Wenning et al.; licensee BioMed Central.

引用

共 5 条

[1]

Mehrabi A., Fischer L., Hafezi M., Dirlewanger A., Grenacher L., Diener M.K., Et al., A systematic review of localization, surgical treatment options, and outcome of insulinoma, Pancreas, 43, 5, pp. 675-686, (2014)

[2]

Shin L.K., Brant-Zawadzki G., Kamaya A., Jeffrey R.B., Intraoperative ultrasound of the pancreas, Ultrasound Q, 25, 1, pp. 39-48, (2009)

[3]

Christ E., Wild D., Ederer S., Behe M., Nicolas G., Caplin M.E., Et al., Glucagon-like peptide-1 receptor imaging for the localisation of insulinomas: a prospective multicentre imaging study, Lancet Diabetes Endocrinol, 1, 2, pp. 115-122, (2013)

[4]

Christ E., Wild D., Forrer F., Brandle M., Sahli R., Clerici T., Et al., Glucagon-like peptide-1 receptor imaging for localization of insulinomas, J Clin Endocrinol Metabolism, 94, 11, pp. 4398-4405, (2009)

[5]

Wild D., Macke H., Christ E., Gloor B., Reubi J.C., Glucagon-like peptide 1-receptor scans to localize occult insulinomas, N Engl J Med, 359, 7, pp. 766-768, (2008)

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