Treatment of severe pulmonary hemorrhage with activated recombinant factor VII (rFVIIa) in very low birth weight infants

被引：27

作者：

Olomu N. ^{[1
]}

Kulkarni R. ^{[2
]}

Manco-Johnson M. ^{[3
]}

机构：

[1] Dept. of Pediatr./Human Development, Division of Neonatology, Michigan University, East Lansing, MI 48909-7980

[2] Dept. of Pediatr./Human Development, Division of Hematology-Oncology, Michigan State University, East Lansing, MI

[3] Mountain States Regional Hemophilia, Thrombosis Center, Univ. of Colorado Hlth. Sci. Center, Aurora, CO

来源：

Journal of Perinatology | 2002年 / 22卷 / 8期

关键词：

D O I：

10.1038/sj.jp.7210787

中图分类号：

学科分类号：

摘要：

Clinically apparent pulmonary hemorrhage (PH) occurs in 5% to 7% of very low birth weight (VLBW) infants with respiratory distress syndrome (RDS). It is associated with mortality rate as high as 50% and significant pulmonary and central nervous system morbilities. There is no consensus on treatment modality. We present two VLBW infants with severe PH that did not respond to conventional treatment but were successfully treated with activated recombinant factor VII (rRVIIa). No untoward side effects were noted.

引用

页码：672 / 674

页数：2

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