Preparation and characteristics of high-amylose corn starch/pectin blend microparticles: A technical note

被引：11

作者：

Desai K.G.H. ^{[1
]}

机构：

[1] School of Life Sciences and Biotechnology, Korea University, Seoul-136-701, 1, 5-Ka, Anam-Dong, Sungbuk-ku

来源：

关键词：

Colon targeted drug delivery; Controlled release; High-amylose corn starch; Kinetics of release; Microparticles; Pectin;

D O I：

10.1208/pt060230

中图分类号：

学科分类号：

摘要：

The HACS/pectin blend microparticles were prepared by spray-drying technique to obtain effective targeted drug release to the colon. The mean particle size of the microparticles (plain and blend) that were prepared in the present study was between 5.8 and 7.3 μm. The microparticles were positively charged (ζ potential was in the range of 20.3 to 30.8), and the encapsulation efficiency was between 80.1% and 94.7%. The blending of HACS with pectin improved the encapsulation efficiency and decreased the drug dissolution in the gastric condition (pH 1.2) from the pectin-based microparticles. Results of the drug release study indicated that the colonic-controlled drug delivery could be obtained from spray-dried HACS/pectin blend microparticles, and the drug release mechanism was found to be by diffusion or erosion or a combination of both. Copyright ©2003. All Rights Reserved.

引用

页码：E202 / E208

页数：6

共 19 条

[1]

Capan Y., Jiang G., Giovagnoli S., Na K.H., DeLuca P.P., Preparation and characterization of poly (D, L-lactide-co-glycolide) microspheres for controlled release of human growth hormones, AAPS PharmSciTech., 4, (2003)

[2]

Schmidt P.C., Niemann F., The MiniWiD-coater: II. Comparison of acid resistance of enteric-coated bisacodyl pellets coated with different polymers, Drug Dev. Ind. Pharm., 18, 18, pp. 1969-1979, (1992)

[3]

Bechard S., Levy L., Clas S., Thermal, mechanical and functional properties of cellulose acetate phthalate (CAP) coatings obtained from neutralized aqueous solutions, Int. J. Pharm., 114, pp. 205-213, (1995)

[4]

Felton L.A., Hasse M.M., Shah N.H., Et al., Physical and enteric properties of soft gelatin capsules coated with Eudragit L 30 D-55, Int. J. Pharm., 113, pp. 17-24, (1995)

[5]

Ashford M., Fell J.T., Attwood D., Sharma H., Woodhead P.J., An in vivo investigation into the suitability of pH dependent polymers for colonic targeting, Int. J. Pharm., 95, pp. 193-199, (1993)

[6]

Englyst H.N., Anderson V., Cummings J.H., Starch and nonstarch polysaccharides in some cereal foods, J. Sci. Food Agric., 34, pp. 1434-1440, (1983)

[7]

Thompson D.B., Strategies for the manufacturer of resistant starch, Trends Food Sci. Technol., 11, pp. 245-253, (2000)

[8]

Chourasia M.K., Jain S.K., Polysaccharides for colon targeted drug delivery, Drug Deliv., 11, pp. 129-148, (2004)

[9]

Liu L., Fishman M., Kost J., Hicks K.B., Pectin-based systems for colon-specific drug delivery via oral route, Biomaterials, 24, pp. 3333-3343, (2003)

[10]

Kim J.H., Fassihi R., Application of a binary polymer system in drug release rate modulation. 1. Characterization of release mechanism, J. Pharm. Sci., 86, pp. 316-322, (1997)

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