The “Hypertension Approaches in the Elderly: a Lifestyle study” multicenter, randomized trial (HAEL Study): rationale and methodological protocol

[1] Lewington S(2017)Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016 Lancet 390 1260-1344

[2] Clarke R(2002)Age-specific relevance of blood pressure to vascular disease in one million people in 61 cohort studies. Prospective studies collaboration Lancet. 360 1903-1913

[3] Qizilbash N(2018)2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines Hypertension 71 1269-1324

[4] Collins RPR(2018)Strategies for achieving healthy vascular aging Hypertension. 71 389-402

[5] Whelton PK(2014)Effect of structured physical activity on prevention of major mobility disability in older adults: the LIFE study randomized clinical trial JAMA. 311 2387-2396

[6] Carey RM(2017)Comparisons of interventions for preventing falls in older adults: a systematic review and meta-analysis JAMA. 318 1687-1699

[7] Aronow WS(2013)Exercise training for blood pressure: a systematic review and meta-analysis J Am Heart Assoc 2 2398-2306

[8] Casey DE(2016)Dynamic resistance training as stand-alone antihypertensive lifestyle therapy: a meta-analysis J Am Heart Assoc 5 248-267

[9] Collins KJ(2016)Is concurrent training efficacious antihypertensive therapy? A meta-analysis Med Sci Sports Exerc 48 e7586-440

[10] Dennison Himmelfarb C(2018)Exercise and other nonpharmacological strategies to reduce blood pressure in older adults: a systematic review and meta-analysis J Am Soc Hypertens 12 431-381

[1] Lewington S(2017)Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016 Lancet 390 1260-1344

[2] Clarke R(2002)Age-specific relevance of blood pressure to vascular disease in one million people in 61 cohort studies. Prospective studies collaboration Lancet. 360 1903-1913

[3] Qizilbash N(2018)2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines Hypertension 71 1269-1324

[4] Collins RPR(2018)Strategies for achieving healthy vascular aging Hypertension. 71 389-402

[5] Whelton PK(2014)Effect of structured physical activity on prevention of major mobility disability in older adults: the LIFE study randomized clinical trial JAMA. 311 2387-2396

[6] Carey RM(2017)Comparisons of interventions for preventing falls in older adults: a systematic review and meta-analysis JAMA. 318 1687-1699

[7] Aronow WS(2013)Exercise training for blood pressure: a systematic review and meta-analysis J Am Heart Assoc 2 2398-2306

[8] Casey DE(2016)Dynamic resistance training as stand-alone antihypertensive lifestyle therapy: a meta-analysis J Am Heart Assoc 5 248-267

[9] Collins KJ(2016)Is concurrent training efficacious antihypertensive therapy? A meta-analysis Med Sci Sports Exerc 48 e7586-440

[10] Dennison Himmelfarb C(2018)Exercise and other nonpharmacological strategies to reduce blood pressure in older adults: a systematic review and meta-analysis J Am Soc Hypertens 12 431-381