A Co(salen)-based metal–organic framework: suppresses breast cancer cell proliferation, migration and invasion

被引：0
作者：
Jin-Cai Wang
Zhen-Lei Shao
Hui-Ling Li
Huai-Yuan Zhu
Hong-Yan Hou
Geng Liu
机构：
[1] The First Affiliated Hospital of Xinxiang Medical University,Department of Pharmacy
来源：
Journal of the Iranian Chemical Society | 2020年 / 17卷
关键词：
Metalloligands; Porous framework; Salen-ligand; Cancer cell;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
In this research, by using the metalloligands approach, a new heterometallic–organic framework has been successfully prepared by one-step synthesis of reacting H4L with metal acetate in water and EtOH mixed solvent, and its chemical formula is {CdNa2(H2O)3[(CoL)2Na(OH)(H2O)]}·6H2O (1, H4L = 3,3′-((1E,1′E)-(cyclohexane-1,2-diylbis(azanylylidene))bis(methanylylidene))bis(4-hydroxybenzoic acid)). In the biological study, the CCK-8 method was exploited to determine the survival rate of MCF7 breast cancer cells after compound treatment. The plate colony formation test was used to confirm the inhibitory effect of this compound on the proliferation of MCF7 cancer cell. Besides, the Annexin V-FITC/PI assay were performed to evaluate the apoptosis of compound-treated MCF7 cells in flow cytometer, the intracellular ROS level was also measured via Reactive Oxygen Species Assay Kit in this study.
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页码：2371 / 2378
页数：7
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