Inhibition of the hepatic Nlrp3 protects dopaminergic neurons via attenuating systemic inflammation in a MPTP/p mouse model of Parkinson’s disease

被引:0
|
作者
Chen Qiao
Qian Zhang
Qingling Jiang
Ting Zhang
Miaomiao Chen
Yi Fan
Jianhua Ding
Ming Lu
Gang Hu
机构
[1] Nanjing Medical University,Jiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology
[2] Nanjing University of Chinese Medicine,Department of Pharmacology
[3] Nanjing Medical University,Neuroprotective Drug Discovery Key Laboratory, Department of Pharmacology
[4] Affiliated Hospital of Jiangsu University,Department of Clinical Pharmacy
[5] Jiangsu University,undefined
来源
Journal of Neuroinflammation | / 15卷
关键词
NLRP3 inflammasome; Systemic inflammation; Neurodegeneration; IL-1β; Parkinson’s disease;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 50 条
  • [41] Gastrodin protects dopaminergic neurons via insulin-like pathway in a Parkinson's disease model
    Yan, Jinyuan
    Yang, Zhongshan
    Zhao, Ninghui
    Li, Zhiwei
    Cao, Xia
    BMC NEUROSCIENCE, 2019, 20 (1)
  • [42] Transgenic expression and activation of PGC-1α protect dopaminergic neurons in the MPTP mouse model of Parkinson’s disease
    Giuseppa Mudò
    Johanna Mäkelä
    Valentina Di Liberto
    Timofey V. Tselykh
    Melania Olivieri
    Petteri Piepponen
    Ove Eriksson
    Annika Mälkiä
    Alessandra Bonomo
    Minna Kairisalo
    Jose A. Aguirre
    Laura Korhonen
    Natale Belluardo
    Dan Lindholm
    Cellular and Molecular Life Sciences, 2012, 69 : 1153 - 1165
  • [43] Estradiol protects dopaminergic neurons in a MPP+Parkinson's disease model
    Sawada, H
    Ibi, M
    Kihara, T
    Honda, K
    Nakamizo, T
    Kanki, R
    Nakanishi, M
    Sakka, N
    Akaike, A
    Shimohama, S
    NEUROPHARMACOLOGY, 2002, 42 (08) : 1056 - 1064
  • [44] c-Jun/Bim Upregulation in Dopaminergic Neurons Promotes Neurodegeneration in the MPTP Mouse Model of Parkinson's Disease
    Hu, Kunhua
    Huang, Qiaoying
    Liu, Chong
    Li, Yongyi
    Liu, Yueyue
    Wang, Hao
    Li, Mingtao
    Ma, Shanshan
    NEUROSCIENCE, 2019, 399 : 117 - 124
  • [45] Transgenic expression and activation of PGC-1α protect dopaminergic neurons in the MPTP mouse model of Parkinson's disease
    Mudo, Giuseppa
    Makela, Johanna
    Di Liberto, Valentina
    Tselykh, Timofey V.
    Olivieri, Melania
    Piepponen, Petteri
    Eriksson, Ove
    Malkia, Annika
    Bonomo, Alessandra
    Kairisalo, Minna
    Aguirre, Jose A.
    Korhonen, Laura
    Belluardo, Natale
    Lindholm, Dan
    CELLULAR AND MOLECULAR LIFE SCIENCES, 2012, 69 (07) : 1153 - 1165
  • [46] Gastrodin protects dopaminergic neurons via insulin-like pathway in a Parkinson’s disease model
    Jinyuan Yan
    Zhongshan Yang
    Ninghui Zhao
    Zhiwei Li
    Xia Cao
    BMC Neuroscience, 20
  • [47] Delivery of CDNF by AAV-mediated gene transfer protects dopamine neurons and regulates ER stress and inflammation in an acute MPTP mouse model of Parkinson's disease
    Nam, Jinhan
    Richie, Christopher T.
    Harvey, Brandon K.
    Voutilainen, Merja H.
    SCIENTIFIC REPORTS, 2024, 14 (01):
  • [48] A selective NLRP3 inflammasome inhibitor attenuates behavioral deficits and neuroinflammation in a mouse model of Parkinson's disease
    Huang, Shuxuan
    Chen, Zhi
    Fan, Binglin
    Chen, Yuan
    Zhou, Liyuan
    Jiang, Bingjian
    Long, Haiyin
    Zhong, Weizhang
    Li, Xiaofeng
    Li, Yanhua
    JOURNAL OF NEUROIMMUNOLOGY, 2021, 354
  • [49] A mitochondrial uncoupler prodrug protects dopaminergic neurons and improves functional outcome in a mouse model of Parkinson's disease
    Kishimoto, Yuki
    Johnson, Joshua
    Fang, William
    Halpern, Joshua
    Marosi, Krisztina
    Liu, Dong
    Geisler, John G.
    Mattson, Mark P.
    NEUROBIOLOGY OF AGING, 2020, 85 : 123 - 130
  • [50] Ellagic Acid Protects Dopamine Neurons via Inhibition of NLRP3 Inflammasome Activation in Microglia
    He, Xue-mei
    Zhou, Yan-zhen
    Sheng, Shuo
    Li, Jing-jie
    Wang, Guo-qing
    Zhang, Feng
    OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2020, 2020