Inhibition of the hepatic Nlrp3 protects dopaminergic neurons via attenuating systemic inflammation in a MPTP/p mouse model of Parkinson’s disease

被引：0
|
作者：
Chen Qiao
Qian Zhang
Qingling Jiang
Ting Zhang
Miaomiao Chen
Yi Fan
Jianhua Ding
Ming Lu
Gang Hu
机构：
[1] Nanjing Medical University,Jiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology
[2] Nanjing University of Chinese Medicine,Department of Pharmacology
[3] Nanjing Medical University,Neuroprotective Drug Discovery Key Laboratory, Department of Pharmacology
[4] Affiliated Hospital of Jiangsu University,Department of Clinical Pharmacy
[5] Jiangsu University,undefined
来源：
Journal of Neuroinflammation | / 15卷
关键词：
NLRP3 inflammasome; Systemic inflammation; Neurodegeneration; IL-1β; Parkinson’s disease;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [31] Brain Selective Estrogen Treatment Protects Dopaminergic Neurons and Preserves Behavioral Function in MPTP-induced Mouse Model of Parkinson's Disease
    Thadathil, Nidheesh
    Xiao, Jianfeng
    Hori, Roderick
    Alway, Stephen E.
    Khan, Mohammad Moshahid
    JOURNAL OF NEUROIMMUNE PHARMACOLOGY, 2021, 16 (03) : 667 - 678
  • [32] Liver X receptor β protects dopaminergic neurons in a mouse model of Parkinson disease
    Dai, Yu-bing
    Tan, Xin-jie
    Wu, Wan-fu
    Warner, Margaret
    Gustafsson, Jan-Ake
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (32) : 13112 - 13117
  • [33] Colchicine Protects Dopaminergic Neurons in a Rat Model of Parkinson's Disease
    Salama, Mohamed
    Ellaithy, Amr
    Helmy, Basem
    El-Gamal, Mohamed
    Tantawy, Dina
    Mohamed, Mie
    Sheashaa, Hussein
    Sobh, Mohamed
    Arias-Carrion, Oscar
    CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS, 2012, 11 (07) : 836 - 843
  • [34] STAT3 protects dopaminergic neurons against degeneration in animal model of Parkinson's disease
    Smit, Rupert D.
    Ghosh, Biswarup
    Campion III, Thomas J.
    Stingel, Rachel
    Lavell, Emily
    Hooper, Robert
    Fan, Xiaoxuan
    Soboloff, Jonathan
    Smith, George M.
    BRAIN RESEARCH, 2024, 1824
  • [35] Inhibition of NLRP3 inflammasome by glibenclamide attenuated dopaminergic neurodegeneration and motor deficits in paraquat and maneb-induced mouse Parkinson's disease model
    Qiu, Xiaofei
    Wang, Qinghui
    Hou, Liyan
    Zhang, Cuili
    Wang, Qingshan
    Zhao, Xiulan
    TOXICOLOGY LETTERS, 2021, 349 : 1 - 11
  • [36] Taurine protects dopaminergic neurons in a mouse Parkinson's disease model through inhibition of microglial M1 polarization
    Che, Yuning
    Hou, Liyan
    Sun, Fuqiang
    Zhang, Cong
    Liu, Xiaofang
    Piao, Fengyuan
    Zhang, Dan
    Li, Huihua
    Wang, Qingshan
    CELL DEATH & DISEASE, 2018, 9
  • [37] Selegiline rescues gait deficits and the loss of dopaminergic neurons in a subacute MPTP mouse model of Parkinson's disease
    Zhao, Qing
    Cai, Dingfang
    Bai, Yu
    INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2013, 32 (04) : 883 - 891
  • [38] Treadmill exercise alleviates neuronal damage by suppressing NLRP3 inflammasome and microglial activation in the MPTP mouse model of Parkinson's disease
    Wang, Wei
    Lv, Ziyan
    Gao, Jin
    Liu, Mengting
    Wang, Yuxin
    Tang, Chuanxi
    Xiang, Jie
    BRAIN RESEARCH BULLETIN, 2021, 174 : 349 - 358
  • [39] Smilagenin Protects Dopaminergic Neurons in Chronic MPTP/Probenecid-Lesioned Parkinson's Disease Models
    He, Xuan
    Yang, Shuangshuang
    Zhang, Rui
    Hou, Lina
    Xu, Jianrong
    Hu, Yaer
    Xu, Rang
    Wang, Hao
    Zhang, Yongfang
    FRONTIERS IN CELLULAR NEUROSCIENCE, 2019, 13
  • [40] NLRP3 inflammasome and glia maturation factor coordinately regulate neuroinflammation and neuronal loss in MPTP mouse model of Parkinson's disease
    Javed, Hayate
    Thangavel, Ramasamy
    Selvakumar, Govindhasamy Pushpavathi
    Dubova, Iuliia
    Schwartz, Noah
    Ahmed, Mohammad Ejaz
    Zaheer, Smita
    Kempuraj, Duraisamy
    Iyer, Shankar
    Zaheer, Asgar
    Khan, Mohammad Moshahid
    INTERNATIONAL IMMUNOPHARMACOLOGY, 2020, 83
12345