Synthesis and properties of ethyl esters of 4-dialkylamino-2-methylthiothieno[2,3-d]-pyrimidine-6-carboxylic acids

被引：0
作者：
S. Tumkevicius
A. Kaminskas
机构：
[1] Faculty of Organic Chemistry, Vilnius University
来源：
Chemistry of Heterocyclic Compounds | 2003年 / 39卷 / 5期
关键词：
Cyclocondensation; Pyrimidines; Reduction; Thieno[2,3-d] pyrimidines;
D O I：
10.1023/A:1025114703659
中图分类号：
学科分类号：
摘要：
The reaction of 4-dialkylamino-6-chloro-2-methylthiopyrimidine-5-carbaldehydes with ethyl mercaptoacetate in the presence of triethylamine gives the corresponding ethyl esters of thieno[2,3-d]-pyrimidine-6-carboxylic acids. These esters were subjected to alkaline hydrolysis, hydrazinolysis, and lithium aluminum hydride reduction to give the corresponding acids, hydrazides, and (thieno[2,3-d]-pyrimidin-6-yl)methanols.
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页码：664 / 668
页数：4
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