TMEM106B and APOE polymorphisms interact to confer risk for late-onset Alzheimer’s disease in Han Chinese

被引：0
作者：
Rui-Chun Lu
Hao Wang
Meng-Shan Tan
Jin-Tai Yu
Lan Tan
机构：
[1] Qingdao University,Department of Neurology, Qingdao Municipal Hospital, School of Medicine
[2] The Affiliated Hospital of the Medical College of Qingdao University,Department of Oncology
[3] Ocean University of China,Department of Neurology, Qingdao Municipal Hospital, College of Medicine and Pharmaceutics
来源：
Journal of Neural Transmission | 2014年 / 121卷
关键词：
Alzheimer’s disease; Polymorphism; TMEM106B; Risk factor; Association study;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Recent large genome-wide association studies have found variants in TMEM106B (top SNP rs1990622) as a strong risk factor for frontotemporal lobar degeneration. Moreover, the TMEM106B risk variant is also implicated in the pathologic presentation of Alzheimer’s disease (AD). Here, we evaluated the association between TMEM106B rs1990622 polymorphism and late-onset AD (LOAD) in a Northern Han Chinese population consists of 1,133 LOAD patients and 1,159 controls. Our data demonstrate that TMEM106B and APOE interact to increase AD risk.
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页码：283 / 287
页数：4
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