Diversification of self-replicating molecules

被引:0
作者
Sadownik J.W. [1 ]
Mattia E. [1 ]
Nowak P. [1 ]
Otto S. [1 ]
机构
[1] University of Groningen, Centre for Systems Chemistry, Stratingh Institute for Chemistry, Nijenborgh 4, AG Groningen
基金
欧洲研究理事会;
关键词
D O I
10.1038/nchem.2419
中图分类号
学科分类号
摘要
How new species emerge in nature is still incompletely understood and difficult to study directly. Self-replicating molecules provide a simple model that allows us to capture the fundamental processes that occur in species formation. We have been able to monitor in real time and at a molecular level the diversification of self-replicating molecules into two distinct sets that compete for two different building blocks (â - foodâ (tm)) and so capture an important aspect of the process by which species may arise. The results show that the second replicator set is a descendant of the first and that both sets are kinetic products that oppose the thermodynamic preference of the system. The sets occupy related but complementary food niches. As diversification into sets takes place on the timescale of weeks and can be investigated at the molecular level, this work opens up new opportunities for experimentally investigating the process through which species arise both in real time and with enhanced detail. © 2016 Macmillan Publishers Limited.
引用
收藏
页码:264 / 269
页数:5
相关论文
共 50 条
[31]   Are Self-Replicating Machines Feasible? [J].
Ellery, Alex .
JOURNAL OF SPACECRAFT AND ROCKETS, 2016, 53 (02) :317-327
[32]   Kinetics of self-replicating micelles [J].
1953, Royal Soc of Chemistry, Letchworth, Engl (90)
[33]   A self-replicating ligase ribozyme [J].
Paul, N ;
Joyce, GF .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (20) :12733-12740
[34]   KINETICS OF SELF-REPLICATING MICELLES [J].
BILLINGHAM, J ;
COVENEY, PV .
JOURNAL OF THE CHEMICAL SOCIETY-FARADAY TRANSACTIONS, 1994, 90 (13) :1953-1959
[35]   Numbering self-replicating polymers [J].
Monteiro, LHA ;
Piqueira, JRC .
JOURNAL OF THEORETICAL BIOLOGY, 1998, 193 (02) :365-367
[36]   Spontaneous Emergence of Self-Replicating Molecules Containing Nucleobases and Amino Acids [J].
Liu, Bin ;
Pappas, Charalampos G. ;
Ottele, Jim ;
Schaeffer, Gael ;
Jurissek, Christoph ;
Pieters, Priscilla F. ;
Altay, Meniz ;
Maric, Nana ;
Stuart, Marc C. A. ;
Otto, Sijbren .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2020, 142 (09) :4184-4192
[37]   SELF-REPLICATING STRUCTURES IN WATER [J].
SPEEDY, RJ .
JOURNAL OF PHYSICAL CHEMISTRY, 1984, 88 (15) :3364-3373
[38]   Self-Replicating Twins in Nanowires [J].
Yuan, Zaoshi ;
Nakano, Aiichiro .
NANO LETTERS, 2013, 13 (10) :4925-4930
[39]   Self-replicating loops: a survey [J].
Tempesti, Gianluca .
INTERNATIONAL JOURNAL OF GENERAL SYSTEMS, 2012, 41 (06) :633-643
[40]   Toward self-replicating robots [J].
Chirikjian, GS ;
Suthakorn, J .
EXPERIMENTAL ROBOTICS VIII, 2003, 5 :392-401