Partial loss of Sorting Nexin 27 resembles age- and Down syndrome-associated T cell dysfunctions

[1] Cullen PJ(2008)Endosomal sorting and signalling: An emerging role for sorting nexins Nat Rev Mol Cell Biol 9 574-582

[2] Cullen PJ(2013)Sorting nexins provide diversity for retromer-dependent trafficking events Introduction : the endosomal network Nat Cell Biol 14 29-37

[3] Korswagen HC(2011)Deficiency of Sorting Nexin 27 (SNX27) Leads to Growth Retardation and Elevated Levels of N -Methyl- d -Aspartate Receptor 2C (NR2C) Mol Cell Biol 31 1734-1747

[4] Cai L(2013)Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down’s syndrome Nat Med 19 473-480

[5] Loo LS(2014)Sorting nexin 27 regulates Aβ production through modulating γ-secretase activity Cell Rep 9 1023-1033

[6] Atlashkin V(2022)Deep immune phenotyping reveals similarities between aging, Down syndrome, and autoimmunity Sci Transl Med 14 4888-24241

[7] Hanson BJ(2019)Trisomy 21 dysregulates T cell lineages toward an autoimmunity-prone state associated with interferon hyperactivity Proc Natl Acad Sci U S A 116 24231-19

[8] Hong W(2016)Trisomy 21 consistently activates the interferon response Elife. 5 e16220-82

[9] Wang X(2022)Sorting Nexin 27 Enables MTOC and Secretory Machinery Translocation to the Immune Synapse Front Immunol 12 1-2028

[10] Zhao Y(2007)Immunological patterns in young children with Down syndrome: Is there a temporal trend? Acta Paediatr Int J Paediatr. 96 1479-14

[1] Cullen PJ(2008)Endosomal sorting and signalling: An emerging role for sorting nexins Nat Rev Mol Cell Biol 9 574-582

[2] Cullen PJ(2013)Sorting nexins provide diversity for retromer-dependent trafficking events Introduction : the endosomal network Nat Cell Biol 14 29-37

[3] Korswagen HC(2011)Deficiency of Sorting Nexin 27 (SNX27) Leads to Growth Retardation and Elevated Levels of N -Methyl- d -Aspartate Receptor 2C (NR2C) Mol Cell Biol 31 1734-1747

[4] Cai L(2013)Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down’s syndrome Nat Med 19 473-480

[5] Loo LS(2014)Sorting nexin 27 regulates Aβ production through modulating γ-secretase activity Cell Rep 9 1023-1033

[6] Atlashkin V(2022)Deep immune phenotyping reveals similarities between aging, Down syndrome, and autoimmunity Sci Transl Med 14 4888-24241

[7] Hanson BJ(2019)Trisomy 21 dysregulates T cell lineages toward an autoimmunity-prone state associated with interferon hyperactivity Proc Natl Acad Sci U S A 116 24231-19

[8] Hong W(2016)Trisomy 21 consistently activates the interferon response Elife. 5 e16220-82

[9] Wang X(2022)Sorting Nexin 27 Enables MTOC and Secretory Machinery Translocation to the Immune Synapse Front Immunol 12 1-2028

[10] Zhao Y(2007)Immunological patterns in young children with Down syndrome: Is there a temporal trend? Acta Paediatr Int J Paediatr. 96 1479-14