J-shaped curve for cardiovascular mortality: systolic or diastolic blood pressure?

被引：0
作者：
Nicolás Roberto Robles
Francesco Fici
Guido Grassi
机构：
[1] Hospital Infanta Cristina,Unidad de Hipertensión
[2] University of Salamanca School of Medicine,Clinica Medica
[3] University of Salamanca School of Medicine,undefined
[4] Università Milano-Bicocca,undefined
[5] IRCCS MultiMedica,undefined
来源：
Journal of Nephrology | 2019年 / 32卷
关键词：
J-curve; Hypertension; Antihypertensive treatment;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Aggressive reduction of blood pressure (BP) may increase cardiovascular events (the J-curve phenomenon) in certain populations. There is a high number of available studies of antihypertensive treatment that provide strong evidence for J-shaped relationships between both diastolic and systolic BP and main cardiovascular outcomes. Nonetheless, most available studies were observational, and randomized trials might not have or lost their statistical power in post-hoc analysis. Contrariwise, most of prospective trial to demonstrate the benefits of intensive blood pressure control were inconclusive. Therefore, further studies are still necessary in order to clarify this issue.
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页码：347 / 353
页数：6
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