Role of acidosis, NMDA receptors, and acid-sensitive ion channel 1a (ASIC1a) in neuronal death induced by ischemia

被引：0
|
作者：
N. K. Isaev
E. V. Stelmashook
E. Y. Plotnikov
T. G. Khryapenkova
E. R. Lozier
Y. V. Doludin
D. N. Silachev
D. B. Zorov
机构：
[1] Lomonosov Moscow State University,Belozersky Institute of Physico
[2] Russian Academy of Medical Sciences,Chemical Biology
[3] Lomonosov Moscow State University,Brain Research Department, Scientific Center of Neurology
来源：
Biochemistry (Moscow) | 2008年 / 73卷
关键词：
acidosis; neurons; ischemia/hypoxia; pH; ASIC1a;
D O I：
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中图分类号：
学科分类号：
摘要：
This review collects data on the influence of intracellular and extracellular acidosis on neuronal viability and the effect of acidosis on neuronal damage progressing under brain ischemia/hypoxia. Particular attention is devoted to the involvement of ionotropic glutamic receptors and acid-sensitive ion channel 1a in these processes.
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