Role of acidosis, NMDA receptors, and acid-sensitive ion channel 1a (ASIC1a) in neuronal death induced by ischemia

被引:0
|
作者
N. K. Isaev
E. V. Stelmashook
E. Y. Plotnikov
T. G. Khryapenkova
E. R. Lozier
Y. V. Doludin
D. N. Silachev
D. B. Zorov
机构
[1] Lomonosov Moscow State University,Belozersky Institute of Physico
[2] Russian Academy of Medical Sciences,Chemical Biology
[3] Lomonosov Moscow State University,Brain Research Department, Scientific Center of Neurology
来源
Biochemistry (Moscow) | 2008年 / 73卷
关键词
acidosis; neurons; ischemia/hypoxia; pH; ASIC1a;
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学科分类号
摘要
This review collects data on the influence of intracellular and extracellular acidosis on neuronal viability and the effect of acidosis on neuronal damage progressing under brain ischemia/hypoxia. Particular attention is devoted to the involvement of ionotropic glutamic receptors and acid-sensitive ion channel 1a in these processes.
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