Role of acidosis, NMDA receptors, and acid-sensitive ion channel 1a (ASIC1a) in neuronal death induced by ischemia

被引：0
作者：
N. K. Isaev
E. V. Stelmashook
E. Y. Plotnikov
T. G. Khryapenkova
E. R. Lozier
Y. V. Doludin
D. N. Silachev
D. B. Zorov
机构：
[1] Lomonosov Moscow State University,Belozersky Institute of Physico
[2] Russian Academy of Medical Sciences,Chemical Biology
[3] Lomonosov Moscow State University,Brain Research Department, Scientific Center of Neurology
来源：
Biochemistry (Moscow) | 2008年 / 73卷
关键词：
acidosis; neurons; ischemia/hypoxia; pH; ASIC1a;
D O I：
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中图分类号：
学科分类号：
摘要：
This review collects data on the influence of intracellular and extracellular acidosis on neuronal viability and the effect of acidosis on neuronal damage progressing under brain ischemia/hypoxia. Particular attention is devoted to the involvement of ionotropic glutamic receptors and acid-sensitive ion channel 1a in these processes.
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