Exosomes derived from human adipose mesenchymal stem cells ameliorate hepatic fibrosis by inhibiting PI3K/Akt/mTOR pathway and remodeling choline metabolism

被引:0
作者
Zilong Zhang
Jin Shang
Qinyan Yang
Zonglin Dai
Yuxin Liang
Chunyou Lai
Tianhang Feng
Deyuan Zhong
Haibo Zou
Lelin Sun
Yuhao Su
Su Yan
Jie Chen
Yutong Yao
Ying Shi
Xiaolun Huang
机构
[1] Sichuan Cancer Hospital & Institute,Liver Transplantation Center and HBP Surgery
[2] Sichuan Cancer Center,School of Medicine
[3] Cancer Hospital Affiliate to University of Electronic Science and Technology of China,undefined
[4] University of Electronic Science and Technology of China,undefined
[5] Department of Core laboratory,undefined
来源
Journal of Nanobiotechnology | / 21卷
关键词
Liver fibrosis; Human adipose mesenchymal stem cells; Exosomes; Metabolomics; Choline;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 50 条
  • [31] Blackberry-Loaded AgNPs Attenuate Hepatic Ischemia/Reperfusion Injury via PI3K/Akt/mTOR Pathway
    Fathi, Ahmed M.
    Waz, Shaimaa
    Alaaeldin, Eman
    Toni, Nisreen D. M.
    El-Sheikh, Azza A. K.
    Sayed, Ahmed M.
    Abdelmohsen, Usama Ramadan
    Nazmy, Maiiada H.
    METABOLITES, 2023, 13 (03)
  • [32] Exosomes derived from mesenchymal stem cells ameliorate renal fibrosis via delivery of miR-186-5p
    Yang, Yiqiong
    Wang, Jing
    Zhang, Yu
    Hu, Xiuxiu
    Li, Li
    Chen, Pingsheng
    HUMAN CELL, 2022, 35 (01) : 83 - 97
  • [33] Exosomes derived from human mesenchymal stem cells promote gastric cancer cell growth and migration via the activation of the Akt pathway
    Gu, Hongbing
    Ji, Runbi
    Zhang, Xu
    Wang, Mei
    Zhu, Wei
    Qian, Hui
    Chen, Yongchang
    Jiang, Pengcheng
    Xu, Wenrong
    MOLECULAR MEDICINE REPORTS, 2016, 14 (04) : 3452 - 3458
  • [34] Exosomes derived from human umbilical cord mesenchymal stem cells promote osteogenesis through the AKT signaling pathway in postmenopausal osteoporosis
    Ren, Shi-Wei
    Cao, Guang-Qing
    Zhu, Qing-Run
    He, Min-Gang
    Wu, Fang
    Kong, Su-Mei
    Zhang, Zhao-Yan
    Wang, Qiang
    Wang, Feng
    AGING-US, 2022, 14 (24): : 10125 - 10136
  • [35] Exosomes derived from mesenchymal stem cells ameliorate renal fibrosis via delivery of miR-186-5p
    Yiqiong Yang
    Jing Wang
    Yu Zhang
    Xiuxiu Hu
    Li Li
    Pingsheng Chen
    Human Cell, 2022, 35 : 83 - 97
  • [36] Extracellular Vesicles from Adipose Tissue Could Promote Metabolic Adaptation through PI3K/Akt/mTOR
    Delgadillo-Velazquez, Jaime
    Mendivil-Alvarado, Herminia
    Daniel Coronado-Alvarado, Carlos
    Astiazaran-Garcia, Humberto
    CELLS, 2022, 11 (11)
  • [37] BMSC Derived Exosomes Attenuate Apoptosis of Temporomandibular Joint Disc Chondrocytes in TMJOA via PI3K/AKT Pathway
    Chen, Wenjun
    Huang, Futing
    Chen, Baoyi
    Lin, Huiyi
    Luo, Guan
    Zhang, Weijun
    Zhang, Xiaoyu
    Zheng, Beining
    Wang, Ziyi
    Wei, Shiting
    He, Jiaxin
    Liu, Chang
    STEM CELL REVIEWS AND REPORTS, 2025, 21 (02) : 491 - 508
  • [38] MEOX2 Participates in Hepatic Stellate Cells-Induced Liver Fibrosis by Regulating the PI3K/AKT Signaling Pathway
    Wang, Qiong
    Li, Ting
    He, Yansha
    Rao, Chunyan
    DISCOVERY MEDICINE, 2024, 36 (185) : 1199 - 1209
  • [39] Exosomes derived from human adipose-derived stem cells ameliorate osteoporosis through miR-335-3p/Aplnr axis
    Sheng, Chunhui
    Guo, Xiaodong
    Wan, Zhuqing
    Bai, Xiaoqiang
    Liu, Hao
    Zhang, Xiao
    Zhang, Ping
    Liu, Yunsong
    Li, Wenyue
    Zhou, Yongsheng
    Lv, Longwei
    NANO RESEARCH, 2022, 15 (10) : 9135 - 9148
  • [40] Exosomes derived from human adipose-derived stem cells ameliorate osteoporosis through miR-335-3p/Aplnr axis
    Chunhui Sheng
    Xiaodong Guo
    Zhuqing Wan
    Xiaoqiang Bai
    Hao Liu
    Xiao Zhang
    Ping Zhang
    Yunsong Liu
    Wenyue Li
    Yongsheng Zhou
    Longwei Lv
    Nano Research, 2022, 15 : 9135 - 9148