Preparation of a glassy carbon electrode modified with reduced graphene oxide and overoxidized electropolymerized polypyrrole, and its application to the determination of dopamine in the presence of ascorbic acid and uric acid

被引：0
作者：
Xia Chen
Dandan Li
Weina Ma
Tianfeng Yang
Yanmin Zhang
Dongdong Zhang
机构：
[1] Xi’an Jiaotong University,School of Pharmacy
来源：
Microchimica Acta | 2019年 / 186卷
关键词：
Graphene; Polypyrrole; Hybrid composite; Nanocomposite; Modified electrode; Neurotransmitter; Electrochemical sensor;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
This paper presents a method for the preparation of a graphene-based hybrid composite film by electrodeposition of reduced graphene oxide and overoxidized electropolymerized polypyrrole onto a glassy carbon electrode (GCE) using cyclic voltammetry. The morphology of the hybrid composite film was characterized by scanning electron microscopy. The electrochemical activity of the modified GCE was studied by cyclic voltammetry using the negatively charged redox probe Fe(CN)63− and the positively charged redox probe Ru(NH3)63+. The modified GCE displays excellent electrocatalytic activity for dopamine (DA) and uric acid (UA), but electrostatically repulses ascorbate anion under physiological pH conditions. The voltammetric response to DA is linear in the 2.0 μM to 160 μM concentration range even in the presence of 1.0 mM ascorbic acid and 0.1 mM of UA. The detection limit is 0.5 μM. The amperometric response to DA (best measured at 0.22 V vs. Ag/AgCl) extends from 0.4 μM to 517 μM and has a 0.2 μM detection limit.
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[1]  
Janezic S(2013)Deficits in dopaminergic transmission precede neuron loss and dysfunction in a new Parkinson model Proc Natl Acad Sci U S A 110 E4016-E4025
[2]  
Threlfell S(2015)Electrochemical analysis of neurotransmitters Annu Rev Anal Chem 8 239-261
[3]  
Dodson PD(2017)In vivo analysis with electrochemical sensors and biosensors Anal Chem 89 300-313
[4]  
Dowie MJ(2017)Electrodeposited reduced graphene oxide incorporating polymerization of l-lysine on electrode surface and its application in simultaneous electrochemical determination of ascorbic acid, dopamine and uric acid Mat Sci Eng C-Mater 70 241-249
[5]  
Taylor TN(2019)Multiwalled carbon nanotube-based nanosensor for ultrasensitive detection of uric acid, dopamine and ascorbic acid Mat Sci Eng C-Mater 99 284-254
[6]  
Potgieter D(2018)Sonication-assisted preparation of a nanocomposite consisting of reduced graphene oxide and CdSe quantum dots, and its application to simultaneous voltammetric determination of ascorbic acid, dopamine and uric acid Microchim Acta 185 456-463
[7]  
Parkkinen L(2018)Simultaneous determination of dopamine and uric acid in the presence of ascorbic acid using a gold electrode modified with carboxylated graphene and silver nanocube functionalized polydopamine nanospheres Microchim Acta 185 382-391
[8]  
Senior SL(2011)Pyrene-loaded polypyrrole microvessels Langmuir 27 12720-12729
[9]  
Anwar S(1995)Electron-transfer pathways in amperometric biosensors. Ferrocenemodified enzymes entrapped in conducting-polymer layers Biosens Bioelectron 10 181-193
[10]  
Ryan B(2006)Synthesis of polypyrrole and carbon nano-fiber composite for the electrode of electrochemical capacitors Mater Lett 60 1697-1701
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