Reduction of serum antioxidative capacity during hemodialysis

被引：36
作者：
Nakayama K. [1 ]
Terawaki H. [1 ]
Nakayama M. [1 ]
Iwabuchi M. [2 ]
Sato T. [2 ]
Ito S. [1 ]
机构：
[1] Research Division of Dialysis and Chronic Kidney Disease, Tohoku University, Graduate School of Medicine, Sendai 980-8574
[2] Department of Blood Purification, Tohoku University, Graduate School of Medicine, Sendai
来源：
Clinical and Experimental Nephrology | 2007年 / 11卷 / 3期
关键词：
Biological antioxidant potential (BAP); Diacron-reactive oxygen metabolites (d-ROM); Hemodialysis; Oxidative stress; Redox state;
D O I：
10.1007/s10157-007-0486-3
中图分类号：
学科分类号：
摘要：
Background. Hemodialysis (HD) is thought to exacerbate oxidative stress (OS). The purpose of this study was to assess patients' oxidative status during and after HD, and to clarify the relation between oxidative status and antioxidant solutes such as uric acid (UA) and ascorbic acid (AsA). Methods. Serum diacron-reactive oxygen metabolites (d-ROM), and biological antioxidant potential (BAP), as well as serum concentrations of UA, AsA, urea nitrogen (UN), and creatinine (Cre) were measured in eight HD patients at six time points during and after HD. Inflow and outflow dialyzer blood was evaluated during HD or sham HD (no dialysate flow). Further, BAP was evaluated by adding UA or AsA to post-HD serum. Results. No changes were found in d-ROM over time, whereas BAP was significantly decreased by HD. No differences were found in d-ROM during HD or sham HD, or between inflow and outflow blood. During HD, significantly lower BAP levels were found in outflow blood than in inflow blood. Serum UA and AsA levels were decreased by HD; however, no increases were obserbed in BAP levels after the addition of these molecules to post-HD serum. Conclusion. These data indicate that HD reduces serum antioxidative capacity, and the loss of dialyzable molecules may be involved. However, this reduction in capacity does not seem to be caused by the loss of UA or AsA. © 2007 Japanese Society of Nephrology.
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页码：218 / 224
页数：6
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