Synthesis of fluorine-containing benzimidazole derivatives

被引：0
作者：
T. P. Vasilyeva
N. M. Karimova
Yu. V. Slavich
机构：
[1] Russian Academy of Sciences,A. N. Nesmeyanov Institute of Organoelement Compounds
来源：
Russian Chemical Bulletin | 2010年 / 59卷
关键词：
Key words; 2-(1,2,2,2-tetrafluoroethyl)-1; -benzimidazole; 2-[(fluoro)trifluoromethoxy-methyl]-1; -benzimidazole; 2-difluoromethyl-1; -benzimidazole; 6- or 5-substituted 2-(1,2,2,2-tetrafluoroethyl)- and 2-[(fluoro)trifluoromethoxymethyl]-1; -benzimidazoles, ; -phenylenediamine; 3,4-diaminotoluene; 1,2-diamino-4-chlorobenzene; hexafluoropropene; perfluoro(methyl vinyl ether); heterocyclization; silylation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Various fluorine-containing benzimidazoles were obtained by the reaction of o-phenylene-diamine, 3,4-diaminotoluene, and 1,2-diamino-4-chlorobenzene with hexafluoropropene or perfluoro(methyl vinyl ether) in DMF. A new efficient method of synthesis of 2-(1,2,2,2-tet-rafluoroethyl)benzimidazole by the reaction of o-phenylenediamine with hexafluoropropene in the presence of diethylamine or dimethylamine in ethyl acetate is developed.
引用
收藏
页码：186 / 191
页数：5
相关论文
共 50 条
  • [41] Synthesis and characterization of poly(amide imides) containing benzimidazole-rings
    Chung, IS
    Kim, SY
    POLYMER BULLETIN, 1997, 38 (06) : 627 - 634
  • [42] Synthesis and characterization of sulphanilamide and benzimidazole pharmacophores containing γ-amino acid derivatives as dual antimicrobial and anticancer agents
    Mackeviciute, Meta
    Vaickelioniene, Rita
    Anusevicius, Kazimieras
    Siugzdaite, Jurate
    Lelesius, Raimundas
    Kavaliauskas, Povilas
    Mickevicius, Vytautas
    ARKIVOC, 2023,
  • [43] Synthesis and Docking Studies of Novel Benzimidazole Derivatives Containing Thiophene and Triazole Rings as Potential Urease Inhibitors
    Akyuz, G.
    Emirik, M.
    Sokmen, B. B.
    Mentese, E.
    RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY, 2022, 48 (SUPPL 1) : S87 - S95
  • [44] Synthesis and Docking Studies of Novel Benzimidazole Derivatives Containing Thiophene and Triazole Rings as Potential Urease Inhibitors
    G. Akyüz
    M. Emirik
    B. B. Sökmen
    E. Menteşe
    Russian Journal of Bioorganic Chemistry, 2022, 48 : S87 - S95
  • [45] Synthesis and pharmacological activity of aroylmethyl derivatives of tricyclic benzimidazole systems containing hydroxy groups in aroyl radicals
    Anisimova V.A.
    Tolpygin I.E.
    Spasov A.A.
    Kosolapov V.A.
    Stepanov A.V.
    Orlova A.A.
    Naumenko L.V.
    Pharmaceutical Chemistry Journal, 2007, 41 (3) : 126 - 130
  • [46] Synthesis of Novel Substituted Thiourea and Benzimidazole Derivatives Containing a Pyrazolone Ring as Anti-Inflammatory Agents
    Moneer, Ashraf A.
    Mohammed, Khaled O.
    El-Nassan, Hala B.
    CHEMICAL BIOLOGY & DRUG DESIGN, 2016, 87 (05) : 784 - 793
  • [47] Synthesis and Characterization of Benzimidazole Derivatives and Evaluation of Antimicrobial activity
    Vyas, Kamal Kant
    Rajpurohit, Sangeeta
    Vaishnav, Yudhishthir
    ORIENTAL JOURNAL OF CHEMISTRY, 2023, 39 (04) : 996 - 1001
  • [48] Synthesis and biological evaluation of Mannich bases of benzimidazole derivatives
    Mariappan, G.
    Bhuyan, N. R.
    Kumar, Pradeep
    Kumar, Deepak
    Murali, K.
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2011, 50 (09): : 1216 - 1219
  • [49] Synthesis, Antimicrobial and Antioxidant Activities of Some Benzimidazole Derivatives
    Kus, Canan
    Ayhan-Kilcigil, Guelguen
    Tuncbilek, Meral
    Altanlar, Nurten
    Coban, Tuelay
    Can-Eke, Benay
    Iscan, Muemtaz
    LETTERS IN DRUG DESIGN & DISCOVERY, 2009, 6 (05) : 374 - 379
  • [50] Applying Nanotechnology in the Synthesis of Benzimidazole Derivatives: A Pharmacological Approach
    El-Sayed, Ahmed A.
    Abu-Bakr, Sherifa M.
    Swelam, Samira A.
    Khaireldin, Nahid Y.
    Shoueir, Kamel R.
    Khalil, Ahmed M.
    BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY, 2022, 12 (01): : 992 - 1005
12345