Synthesis of fluorine-containing benzimidazole derivatives

被引：0
|
作者：
T. P. Vasilyeva
N. M. Karimova
Yu. V. Slavich
机构：
[1] Russian Academy of Sciences,A. N. Nesmeyanov Institute of Organoelement Compounds
来源：
Russian Chemical Bulletin | 2010年 / 59卷
关键词：
Key words; 2-(1,2,2,2-tetrafluoroethyl)-1; -benzimidazole; 2-[(fluoro)trifluoromethoxy-methyl]-1; -benzimidazole; 2-difluoromethyl-1; -benzimidazole; 6- or 5-substituted 2-(1,2,2,2-tetrafluoroethyl)- and 2-[(fluoro)trifluoromethoxymethyl]-1; -benzimidazoles, ; -phenylenediamine; 3,4-diaminotoluene; 1,2-diamino-4-chlorobenzene; hexafluoropropene; perfluoro(methyl vinyl ether); heterocyclization; silylation;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Various fluorine-containing benzimidazoles were obtained by the reaction of o-phenylene-diamine, 3,4-diaminotoluene, and 1,2-diamino-4-chlorobenzene with hexafluoropropene or perfluoro(methyl vinyl ether) in DMF. A new efficient method of synthesis of 2-(1,2,2,2-tet-rafluoroethyl)benzimidazole by the reaction of o-phenylenediamine with hexafluoropropene in the presence of diethylamine or dimethylamine in ethyl acetate is developed.
引用
收藏
页码：186 / 191
页数：5
相关论文
共 50 条
  • [1] Synthesis of fluorine-containing benzimidazole derivatives
    Vasilyeva, T. P.
    Karimova, N. M.
    Slavich, Yu. V.
    RUSSIAN CHEMICAL BULLETIN, 2010, 59 (01) : 186 - 191
  • [2] SYNTHESIS OF FLUORINE-CONTAINING FUNCTIONAL DERIVATIVES OF ADAMANTANE
    KHARDIN, AP
    POPOV, AD
    PROTOPOPOV, PA
    ZHURNAL VSESOYUZNOGO KHIMICHESKOGO OBSHCHESTVA IMENI D I MENDELEEVA, 1976, 21 (05): : 593 - 594
  • [3] Synthesis and fungicidal activity of fluorine-containing chlorothalonil derivatives
    Guan, Aiying
    Liu, Changling
    Huang, Guang
    Li, Huichao
    Hao, Shulin
    Xu, Ying
    Xie, Yong
    JOURNAL OF FLUORINE CHEMISTRY, 2014, 160 : 82 - 87
  • [4] The synthesis and herbicidal evaluation of fluorine-containing phenoxyacetoxyalkylphosphonate derivatives
    Chen, Ting
    Shen, Ping
    Li, Yanjun
    He, Hongwu
    PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2006, 181 (09) : 2135 - 2145
  • [5] SYNTHESIS OF FLUORINE-CONTAINING DL-ALANINE DERIVATIVES
    MAKI, Y
    INUKAI, K
    JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, 1976, 34 (10) : 722 - 725
  • [6] Fluorine-Containing Chrysin Derivatives: Synthesis and Biological Activity
    Zhu, Yue
    Yao, Xu
    Long, Jin
    Li, Rong
    Liu, Yi
    Yang, ZeHua
    Zheng, Xing
    NATURAL PRODUCT COMMUNICATIONS, 2019, 14 (09)
  • [7] SYNTHESIS OF SOME FLUORINE-CONTAINING ANALOGS AND DERIVATIVES OF MEDICINALS
    MINOR, JT
    VANDERWERF, CA
    JOURNAL OF ORGANIC CHEMISTRY, 1952, 17 (11): : 1425 - 1430
  • [8] Stereocontrolled Synthesis of Fluorine-Containing Piperidine γ-Amino Acid Derivatives
    Ouchakour, Lamiaa
    Abrahami, Renata A.
    Forro, Eniko
    Haukka, Matti
    Fulop, Ferenc
    Kiss, Lorand
    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2019, 2019 (12) : 2202 - 2211
  • [9] SYNTHESIS AND PHARMACOLOGICAL PROPERTIES OF SOME FLUORINE-CONTAINING AMIDE DERIVATIVES
    JORDIN, MW
    EASTERLY, WD
    WINNINGHAM, TE
    HUBBARD, WC
    JOURNAL OF PHARMACEUTICAL SCIENCES, 1965, 54 (08) : 1190 - +
  • [10] Fluorine-containing pyrazoles and their condensed derivatives: Synthesis and biological activity
    Lipunova, Galina N.
    Nosova, Emiliya V.
    Charushin, Valery N.
    Chupakhin, Oleg N.
    JOURNAL OF FLUORINE CHEMISTRY, 2015, 175 : 84 - 109
12345