Epstein–Barr Virus-Positive Diffuse Large B cell Lymphoma in the Experience of a Tertiary Medical Center in Poland

被引：0
作者：
Mateusz Ziarkiewicz
Dominika Wołosz
Tomasz Dzieciątkowski
Ewa Wilczek
Jadwiga Dwilewicz-Trojaczek
Wiesław Wiktor Jędrzejczak
Beata Gierej
Bogna Ziarkiewicz-Wróblewska
机构：
[1] Medical University of Warsaw,Department of Hematology, Oncology and Internal Medicine
[2] Medical University of Warsaw,Department of Pathology, Center for Biostructure Research
[3] Central Clinical Hospital,Department of Microbiology
[4] Medical University of Warsaw,Chair and Department of Medical Microbiology
来源：
Archivum Immunologiae et Therapiae Experimentalis | 2016年 / 64卷
关键词：
Diffuse large B cell lymphoma; DLBCL; Epstein–Barr virus; EBV; EBV-positive DLBCL of the elderly; EBER; EBV serology;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The role of Epstein–Barr virus (EBV) in the biology and clinical characteristics of diffuse large B cell lymphoma (DLBCL) is still poorly defined. A new provisional entity EBV-positive DLBCL of the elderly has been described in Asian population. Its incidence and prognosis remains unknown in middle European patients. Clinical data and tissue samples were collected from 74 Caucasian patients with DLBCL, aged between 23 and 86 years, treated at a single institution. Lymphoma morphology was reassessed, laboratory procedures included in situ hybridization specific for EBV-encoded small RNAs (EBER), immunohistochemical staining for latent membrane protein and serological testing for EBV-specific antibodies. EBER staining revealed 12.2 % of EBV-positive cases, whereas 9.5 % were diagnosed as EBV-positive DLBCL of the elderly. Serologic EBV markers did not correlate with the presence of EBV in tissue samples (P > 0.10). Elderly EBV-positive cases had lower BCL-6 (P = 0.038) and higher CD30 (P = 0.049) expression and were characterized by higher progression risk (median time-to-progression 12.5 months vs not reached; P = 0.029) and a trend towards worse overall survival (median overall survival 24.5 months vs not reached; P = 0.059). EBV-positive DLBCL of the elderly occurs relatively frequently in Polish population and may be associated with inferior prognosis in comparison with DLBCL, not otherwise specified.
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页码：159 / 169
页数：10
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