Effects of Drotaverine Hydrochloride on Viability of Rat Cultured Cerebellar Granulocytes

被引：0
|
作者：
V. P. Demushkin
E. V. Zhavoronkova
L. G. Khaspekov
机构：
[1] Russian Academy of Sciences,Laboratory of Peptide Chemistry, M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Organic Biochemistry
[2] the Russian Academy of Medical Sciences,Laboratory of Experimental Neurocytology, Research Center of Neurology
来源：
Bulletin of Experimental Biology and Medicine | 2012年 / 152卷
关键词：
drotaverine; cerebellar granulocyte culture; neurocytotoxicity; stroke;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The neurocytotoxic effect of drotaverine hydrochloride was studied in culture of rat cerebellar granulocytes. Incubation of cells with 100 and 250 μM drotaverine reduced neuronal survival to 60 and 4%, respectively.
引用
收藏
页码：444 / 446
页数：2
相关论文
共 50 条
  • [31] Adenosine and ADP prevent apoptosis in cultured rat cerebellar granule cells
    Vitolo, OV
    Ciotti, MT
    Galli, C
    Borsello, T
    Calissano, P
    BRAIN RESEARCH, 1998, 809 (02) : 297 - 301
  • [32] Melatonin inhibits nicotinic currents in cultured rat cerebellar granule neurons
    Lax, Pedro
    JOURNAL OF PINEAL RESEARCH, 2008, 44 (01) : 70 - 77
  • [33] VOLTAGE DEPENDENT SODIUM CURRENTS IN CULTURED RAT CEREBELLAR GRANULE CELLS
    LIN, F
    MORAN, O
    BIOSCIENCE REPORTS, 1990, 10 (05) : 445 - 453
  • [34] NEUROPROTECTIVE EFFECTS OF CARVEDILOL, A NEW ANTIHYPERTENSIVE AGENT, IN CULTURED RAT CEREBELLAR NEURONS AND IN GERBIL GLOBAL BRAIN ISCHEMIA
    LYSKO, PG
    LYSKO, KA
    YUE, TL
    WEBB, CL
    GU, JL
    FEUERSTEIN, G
    STROKE, 1992, 23 (11) : 1630 - 1636
  • [35] NEUROPROTECTIVE EFFECTS OF SKF-10,047 IN CULTURED RAT CEREBELLAR NEURONS AND IN GERBIL GLOBAL BRAIN ISCHEMIA
    LYSKO, PG
    GAGNON, RC
    YUE, TL
    GU, JL
    FEUERSTEIN, G
    STROKE, 1992, 23 (03) : 414 - 419
  • [36] EFFECTS OF AMYLOID-β PEPTIDE ON GLUTAMINE TRANSPORTER MRNA EXPRESSION AND CELL VIABILITY IN CULTURED RAT CORTICAL CELLS
    Thangnipon, W.
    Buntup, D.
    Chayasadom, A.
    Surarit, R.
    Jutapakdeegul, N.
    JOURNAL OF NEUROCHEMISTRY, 2009, 110 : 65 - 65
  • [37] Effects of amyloid-β peptide on glutamine transporter mRNA expression and cell viability in cultured rat cortical cells
    Buntup, Doungjai
    Chayasadom, Anek
    Surarit, Rudee
    Jutapakdeegul, Nuanchan
    Thangnipon, Wipawan
    SCIENCEASIA, 2009, 35 (02): : 156 - 160
  • [38] Effects of peroxisome proliferator-activated receptor γ ligands ciglitazone and 15-Deoxy-Δ12,14-prostaglandin J2 on rat cultured cerebellar granule neuronal viability
    Smith, SA
    Monteith, GR
    Holman, NA
    Robinson, JA
    May, FJ
    Roberts-Thomson, SJ
    JOURNAL OF NEUROSCIENCE RESEARCH, 2003, 72 (06) : 747 - 755
  • [39] TERATOGENIC EFFECTS OF CHLORPROMAZINE HYDROCHLORIDE IN RAT FETUSES
    SINGH, S
    PADMANABHAN, R
    INDIAN JOURNAL OF MEDICAL RESEARCH, 1978, 67 (FEB) : 300 - 309
  • [40] EFFECTS OF PHENCYCLIDINE HYDROCHLORIDE ON NEUROENDOCRINE FUNCTION IN THE RAT
    PECHNICK, RN
    GEORGE, R
    POLAND, RE
    PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1987, 28 (01) : 136 - 136
12345