Effects of Drotaverine Hydrochloride on Viability of Rat Cultured Cerebellar Granulocytes

被引:0
|
作者
V. P. Demushkin
E. V. Zhavoronkova
L. G. Khaspekov
机构
[1] Russian Academy of Sciences,Laboratory of Peptide Chemistry, M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Organic Biochemistry
[2] the Russian Academy of Medical Sciences,Laboratory of Experimental Neurocytology, Research Center of Neurology
关键词
drotaverine; cerebellar granulocyte culture; neurocytotoxicity; stroke;
D O I
暂无
中图分类号
学科分类号
摘要
The neurocytotoxic effect of drotaverine hydrochloride was studied in culture of rat cerebellar granulocytes. Incubation of cells with 100 and 250 μM drotaverine reduced neuronal survival to 60 and 4%, respectively.
引用
收藏
页码:444 / 446
页数:2
相关论文
共 50 条
  • [21] TESTICULAR EFFECTS OF CYCLOHEXYLAMINE HYDROCHLORIDE IN RAT
    MASON, PL
    THOMPSON, GR
    TOXICOLOGY, 1977, 8 (02) : 143 - 156
  • [22] Effects of rat embryonic neurospheres on the viability of cultured postmortem brain tissue slices from AD patients
    Wu, L
    Verwer, RWH
    Swaab, DF
    Zhou, JN
    NEUROBIOLOGY OF AGING, 2004, 25 : S83 - S83
  • [23] Effects of Redox Modulation on Cell Proliferation, Viability, and Migration in Cultured Rat and Human Tendon Progenitor Cells
    Lee, Yuk Wa
    Fu, Sai Chuen
    Yeung, Man Yi
    Lau, Chun Man Lawrence
    Chan, Kai Ming
    Hung, Leung Kim
    OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2017, 2017
  • [24] The desglycinyl metabolite of remacemide hydrochloride is neuroprotective in cultured rat cortical neurons
    Black, MA
    Tremblay, R
    Mealing, GAR
    Durkin, JP
    Whitfield, JF
    Morley, P
    JOURNAL OF NEUROCHEMISTRY, 1996, 66 (03) : 989 - 995
  • [25] Role of reactive nitrogen species in the viability of cultured cerebellar granule neurons under proapoptotic conditions
    Ramos-Pittol, J. M.
    Moran, J.
    JOURNAL OF NEUROCHEMISTRY, 2007, 102 : 49 - 50
  • [26] POLYAMINES AFFECT GROWTH OF CULTURED RAT CEREBELLAR NEURONS IN DIFFERENT SERA
    GILAD, GM
    GILAD, VH
    INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, 1986, 4 (03) : 195 - &
  • [27] Regulation of sodium pump isoforms in cultured rat cerebellar granule cells
    Soga, T
    Inoue, N
    Nakayama, T
    Kato, T
    NA/K-ATPASE AND RELATED ATPASES, 2000, 1207 : 603 - 606
  • [28] EXCITOTOXIC DEGENERATION IS INITIATED AT NONRANDOM SITES IN CULTURED RAT CEREBELLAR NEURONS
    BINDOKAS, VP
    MILLER, RJ
    JOURNAL OF NEUROSCIENCE, 1995, 15 (11): : 6999 - 7011
  • [29] Oleamide attenuates apoptotic death in cultured rat cerebellar granule neurons
    Yang, JY
    Abe, K
    Xu, NJ
    Matsuki, N
    Wu, CF
    NEUROSCIENCE LETTERS, 2002, 328 (02) : 165 - 169
  • [30] GLIAL CONDITIONED MEDIA INHIBIT THE PROLIFERATION OF CULTURED RAT CEREBELLAR ASTROCYTES
    ALOISI, F
    AGRESTI, C
    LEVI, G
    NEUROCHEMICAL RESEARCH, 1987, 12 (02) : 189 - 195