Hemodynamic and neurohumoral profile in patients with different types of hypertension in pregnancy

被引:0
作者
Claudio Borghi
Arrigo Francesco Giuseppe Cicero
Daniela Degli Esposti
Vincenzo Immordino
Stefano Bacchelli
Nicola Rizzo
Francesca Santi
Ettore Ambrosioni
机构
[1] S. Orsola-Malpighi University Hospital,Department of Internal Medicine, Aging and Kidney Diseases
[2] S. Orsola-Malpighi University Hospital,Department of Obstetrics and Gynecology
来源
Internal and Emergency Medicine | 2011年 / 6卷
关键词
Hypertension; Pregnancy; Left ventricular function; Plasma renin activity; Pre-eclampsia;
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学科分类号
摘要
Hypertension in pregnancy is a frequent disorder that includes a spectrum of conditions. We aimed at comparatively evaluating the hemodynamic, echocardiographic and biohumoral profile of a sample of pregnant Caucasian women with different form of pregnancy-related hypertension. We enrolled 39 non-hypertensive pregnant women (NP), 26 with Chronic HBP in pregnancy (CH), 24 with gestational hypertension (G-PIH), and 33 with pre-eclampsia. We recorded and compared blood pressure (BP), echocardiographic parameters, resting plasma renin activity (PRA) and plasma aldosterone (PA), Plasma levels of atrial (ANP) and brain natriuretic peptide (BNP). PE patients had a significantly higher BP than either G-PIH or NP patients. PE patients had also significantly lower cardiac output than NP, G-PIH and CH. In comparison to NP patients, the total peripheral vascular resistance was 61% higher in PE women and 38% higher in CH patients. All echographic parameters were significantly more altered in PE patients when compared with NP, in respect to any other form of hypertension. Either ANP (+35%) and BNP (+40%) were significantly higher in PE patients than in controls. The PRA was reduced in PE and CH patients when compared either with NP (−38 and −35%, respectively) or G-PIH (−47 and −43%, respectively). On the basis of our data, we can conclude that PE is the gestation associated hypertension with the largest anatomical, functional and biohumoral involvement, and so it has to be involved in a more intensive monitoring and evaluation.
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页码:227 / 234
页数:7
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