Acute effects of sildenafil on Humphrey visual field and intraocular pressure

被引:9
作者
Ermis S.S. [1 ,3 ]
Inan U.U. [1 ]
Samli M. [2 ]
Ozturk F. [1 ]
机构
[1] Department of Ophthalmology, School of Medicine, University of Afyon Kocatepe, Afyon
[2] Department of Urology, School of Medicine, University of Afyon Kocatepe, Afyon
[3] 03200 Afyon, Dervispasa mah. Pirireis sk.
关键词
Intraocular pressure; Sildenafil; Visual field;
D O I
10.1023/B:INTE.0000031735.45526.1c
中图分类号
学科分类号
摘要
Purpose: To evaluate the effects of sildenafil on visual field and intraocular pressure in a group of healthy subjects. Methods: Twenty-eight healthy male volunteers with normal eyes were included in the study. Visual field examinations were performed using FASTPAC 30-2 program (white-on-white and blue-on-yellow) with the Humphrey field analyzer before and one hour after receiving oral 50 and 100 mg sildenafil citrate. Results: The mean age was 51.1 ± 8.9 years. Mean deviation, pattern standard deviation, short-term fluctuation and corrected pattern standard deviation did not differ significantly among tests both in white-on-white and blue-on-yellow visual field examinations. Changes in intraocular pressure were not statistically significant. Conclusions: No significant effect of sildenafil was seen on visual field and intraocular pressure in healthy subjects. © 2004 Kluwer Academic Publishers.
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页码:69 / 72
页数:3
相关论文
共 19 条
[1]  
Jeremy Y.J., Ballard S.A., Nylor A.M., Miller M.A.W., Angelini G.D., Effects of sildenafil, a type 5 cGMP phosphodiesterase inhibitor, and papaverin on cyclic GMP and cyclic AMP levels in the rabbit corpus cavernosum in vitro, Br. J. Urol., 79, pp. 958-963, (1997)
[2]  
Ballard S.A., Gingel C.J., Tang K., Turner L.A., Price M.E., Nylor A.M., Effects of sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes, J. Urol., 159, pp. 2164-2171, (1998)
[3]  
Walman S.A., Murad F., Cyclic GMP synthesis and function, Pharmacol. Rev., 39, pp. 163-196, (1987)
[4]  
Marmor M.F., Sildenafil (Viagra) and ophthalmology, Arch. Ophtalmol., 117, pp. 518-519, (1999)
[5]  
Marmor M.F., Kessler R., Sildenafil (Viagra) and ophthalmology, Surv. Ophthalmol., 44, pp. 153-162, (1999)
[6]  
Schneider T., Zrenner E., The influence of phosphodiesterase inhibitors on ERG and optic nerve response of the cat, Invest. Ophthalmol. Vis. Sci., 27, pp. 1395-1403, (1986)
[7]  
Zrenner E., Electrophysiological characteristics of the blue sensitive mechanism: Test of a model of cone interaction under physiological and pathological conditions, Doc. Ophthalol. Proc. Ser., 33, pp. 103-125, (1982)
[8]  
Vobig M.A., Klotz T., Staak M., Bartz-Schmidt K.U., Engelmann U., Walter P., Retinal side effects of sildenafil, Lancet, 353, (1999)
[9]  
Gabrielli C.B., Regine F., Vingolo E.M., Rispoli E., Fabbri A., Isidori A., Subjective visual halos after sildenafil (Viagra) administration, Ophthalmology, 108, pp. 877-881, (2001)
[10]  
Pache M., Meyer P., Prunte C., Orgul S., Nuttli I., Flammer J., Sildenafil induces retinal vasodilatation in healthy subjects, Br. J. Ophthalmol., 86, pp. 156-158, (2002)