AMicro-sized headspace GC technique for determination of organic volatile impurities in water-insoluble pharmaceuticals

被引:0
|
作者
L. Hong
H. Alforfer
机构
[1] Swiss Federal Institute of Technology (ETH),Institute of Pharmaceutical Science
来源
Chromatographia | 2001年 / 53卷
关键词
Gas chromatography; Headspace sampling; Miniaturization; Volatile organics; Water-insoluble pharmaceuticals;
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学科分类号
摘要
A micro-sized headspace technique is presented for determination of organic volatile impurities (OVIs) in water-insoluble pharmaceuticals. Its main features include reduction of the amounts of sample of drug and sample dissolution medium, from 100–200 mg and 1–5 mL, respectively, in the traditional headspace method to 5–30 mg and 100 μL in the micro-sized headspace method, and shortening the headspace equilibration time from 45–60 min to 5–10 min.
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页码:76 / 80
页数:4
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