The complexity of G-protein coupled receptor-ligand interactions

被引：0
作者：
Ting Wang
机构：
[1] University of California,Genome Center
来源：
Science China Chemistry | 2013年 / 56卷
关键词：
G-protein coupled receptors (GPCR); ligand; interaction; functional selectivity; receptor subtype;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The G-protein coupled receptors (GPCRs) play fundamental roles in the human biololgy and drug discovery. GPCRs function as signalling molecules that transduce extracellular signals into cells. The signalling transduction is generally triggered by interacting with ligands, including photons, ions, small organic compounds, peptides, proteins and lipids. In this review, we focus on interactions with diffusible ligands such as hormones and neurotransmitters. We discuss three aspects of the complexity of the GPCR-ligand interactions: functional selectivity of ligands, receptor subtype selectivity of ligands and orphan GPCRs.
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页码：1344 / 1350
页数：6
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