New Drugs in the Management of the Irritable Bowel Syndrome

被引:0
作者
Michael J. G. Farthing
机构
[1] St Bartholomew’s and the Royal London School of Medicine and Dentistry,Digestive Diseases Research Centre
来源
Drugs | 1998年 / 56卷
关键词
Adis International Limited; Irritable Bowel Syndrome; Granisetron; Sodium Cromoglycate; Irritable Bowel Syndrome Patient;
D O I
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学科分类号
摘要
Irritable bowel syndrome (IBS) continues to provide a major therapeutic challenge to clinicians and those involved in drug development. It seems unlikely from the data before us that this multisymptom syndrome with peripheral and central components is likely to respond reliably in all patients to the same single agent. There is still a lack of well designed, appropriately powered, randomised clinical trials and the problems of dealing with the high placebo response rate in this group of patients remains a dilemma for trial designers.
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页码:11 / 21
页数:10
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  • [1] Farthing MJG(1995)Irritable bowel, irritable body, irritable brain? BMJ 310 171-5
  • [2] Klein KB(1977)Controlled treatment trials in the irritable bowel syndrome: a critique Gastroenterology 95 232-41
  • [3] Manning AP(1978)Towards positive diagnosis of the irritable bowel BMJ II 653-4
  • [4] Thompson WG(1992)Functional bowel disease and functional abdominal pain Gastroenterol Int 5 75-91
  • [5] Heaton KW(1986)Non-colonic features of irritable bowel syndrome Gut 27 37-40
  • [6] Thompson WG(1993)Community study reveals that dysfunctional illness attitudes in irritable bowel syndrome are not wholly a reflection of patient status [abstract] Gastroenterology 104 A513-30
  • [7] Creed F(1995)Abdominal illness attitudes in irritable bowel syndrome J Psychosom Res 39 227-4
  • [8] Drossman DA(1994)Selective affective biasing in recognition memory in the irritable bowel syndrome Gut 34 1230-84
  • [9] Whorwell PJ(1994)Intestinal motor function in irritable bowel syndrome Dig Dis Sci 12 72-704
  • [10] McCallum M(1990)The role of visceral afferent mechanisms in functional bowel disorders Gastroenterology 99 1688-8