Successful pregnancy and full-term delivery after atypical polypoid adenomyoma of the uterus and recurrent cervical intraepithelial neoplasia 3

We describe a conservative treatment for atypical polypoid adenomyoma (APA) of the uterus and cervical intraepithelial neoplasia (CIN) 3 followed by a spontaneous pregnancy and full-term delivery in a 27-year-old woman. The patient presented with CIN 3 and underwent repeated Shimodaira–Taniguchi conization and treatment for APA. Medroxyprogesterone acetate (MPA) and low-dose aspirin were administered for 9 months followed by a hysteroscopic transcervical resection (TCR) of residual lesions. Atypical glands were <1 % of all glands. Three months later, the endometrium was fully recovered and biopsies revealed no atypical cells. Further 3 months later, the patient spontaneously conceived and gave birth to a healthy baby boy at full term. To the best of our knowledge, this is the first report on the use of MPA and TCR for treatment of APA patients, followed by a successful pregnancy outcome.