Heterogeneity of chemical modifications on RNA

被引：0
作者：
W. S. Sho Goh
Yi Kuang
机构：
[1] Institute of Molecular Physiology,Department of Chemical and Biological Engineering
[2] Shenzhen Bay Laboratory,undefined
[3] The Hong Kong University of Science and Technology,undefined
来源：
Biophysical Reviews | 2024年 / 16卷
关键词：
RNA modification; Epitranscriptome; Heterogeneity; Single-cell RNA sequencing;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The chemical modifications of RNAs broadly impact almost all cellular events and influence various diseases. The rapid advance of sequencing and other technologies opened the door to global methods for profiling all RNA modifications, namely the “epitranscriptome.” The mapping of epitranscriptomes in different cells and tissues unveiled that RNA modifications exhibit extensive heterogeneity, in type, amount, and in location. In this mini review, we first introduce the current understanding of modifications on major types of RNAs and the methods that enabled their discovery. We next discuss the tissue and cell heterogeneity of RNA modifications and briefly address the limitations of current technologies. With much still remaining unknown, the development of the epitranscriptomic field lies in the further developments of novel technologies.
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页码：79 / 87
页数：8
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