Analysis of Gut Microbiota in Patients with Parkinson’s Disease

被引：0

作者：

V. A. Petrov

I. V. Saltykova

I. A. Zhukova

V. M. Alifirova

N. G. Zhukova

Yu. B. Dorofeeva

A. V. Tyakht

B. A. Kovarsky

D. G. Alekseev

E. S. Kostryukova

Yu. S. Mironova

O. P. Izhboldina

M. A. Nikitina

T. V. Perevozchikova

E. A. Fait

V. V. Babenko

M. T. Vakhitova

V. M. Govorun

A. E. Sazonov

机构：

[1] Siberian State Medical University,

[2] Ministry of Health of the Russian Federation,undefined

[3] Federal Research and Clinical Center of Physical-Chemical Medicine,undefined

[4] Federal Medical Biological Agency,undefined

[5] M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry,undefined

[6] M. V. Lomonosov Moscow State University,undefined

来源：

Bulletin of Experimental Biology and Medicine | 2017年 / 162卷

关键词：

gut microbiota; Parkinson’s disease; 16S rRNA sequencing;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Gut microbiota of patients with Parkinson’s disease and healthy volunteers was analyzed by the method of high throughput 16S rRNA sequencing of bacterial genomes. In patients with Parkinson’s diseases, changes in the content of 9 genera and 15 species of microorganisms were revealed: reduced content of Dorea, Bacteroides, Prevotella, Faecalibacterium, Bacteroides massiliensis, Stoquefichus massiliensis, Bacteroides coprocola, Blautia glucerasea, Dorea longicatena, Bacteroides dorei, Bacteroides plebeus, Prevotella copri, Coprococcus eutactus, and Ruminococcus callidus, and increased content of Christensenella, Catabacter, Lactobacillus, Oscillospira, Bifidobacterium, Christensenella minuta, Catabacter hongkongensis, Lactobacillus mucosae, Ruminococcus bromii, and Papillibacter cinnamivorans. This microbiological pattern of gut microflora can trigger local inflammation followed by aggregation of α-synuclein and generation of Lewy bodies.

引用

页码：734 / 737

页数：3

共 133 条

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