Absolute Configuration of Stizolicin and Synthesis and Biological Activity of Its Amino Derivatives

被引：0
作者：
E. M. Suleimenov
V. A. Raldugin
Yu. V. Gatilov
I. Yu. Bagryanskaya
R. Seidakhmetova
R. M. Aksartov
S. M. Adekenov
机构：
[1] Ministry of Education and Science of the Republic of Kazakhstan,Institute of Phytochemistry
[2] Russian Academy of Sciences,N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division
来源：
Chemistry of Natural Compounds | 2005年 / 41卷
关键词：
germacranolides; PMR; x-ray structure analysis; antimicrobial activity;
D O I：
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中图分类号：
学科分类号：
摘要：
Reaction of the germacranolide stizolicin with secondary amines formed normal products of a Michael reaction at the exomethylene group and simultaneously led to solvolysis with cleavage of the acyl group. The structures of the molecules were established by XSA. Use of the HI salt of one of the resulting amines enabled the proof of its absolute configuration and that of the starting stizolicin, which had previously only been proposed. Stizolicin and the synthesized compounds were screened for antimicrobial and antitrichomonal activity.
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页码：561 / 564
页数：3
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