Chongmyungtang attenuates kainic acid-induced seizure and mortal effect in the mouse

被引：0
作者：
Kyung-Jin Jang
Kyou-Heung Lee
Sang-Lin Kim
Dong-Young Choi
Beom-Kyu Park
Doo-Hyun Im
Yong-Joon Cho
Wang-Kee Jhoo
Hyoung-Chun Kim
机构：
[1] Boryung Pharmaceutical Central Research Institute,College of Pharmacy
[2] Kangwon National University,undefined
来源：
Archives of Pharmacal Research | 1997年 / 20卷
关键词：
Chongmyungtang; Neuroprotective effect; Kainic acid-induced neurotoxicity;
D O I：
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摘要：
TheChongmyungtang (CMT; the combination ofAcorus gramineus, polygala tenuifolia andPoria cocos) has been recognized to possess the preventive effect against several neurologic disorders in human. In this study, we examined the effect of CMT on the three parameters associated with kainic acid (KA)-induced neurotoxicities; seizure/mortality, increased fos-related antigen (FRA) and glial fibrillary acidic protein (GFAP) expression. KA induced vigorous convulsions lasting 4–6 hr. Pretreatments with CMT before KA injection significantly reduced the seizure intensity as well as the mortality. CMT pretreatments also attenuated the KA-induced increase in FRA/GFAP expression in the hippocampus. These results suggest that CMT has a neuroprotective effect against KA-induced neurotoxicities.
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页码：375 / 378
页数：3
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  • [1] Bing G.(1996)Long-term expression of the 35000 mol wt. Fos-related antigen in rat brain after kainic acid treatment Neuroscience 73 1159-1174
  • [2] McMillian M.(1995)Spatial memory deficits, increased phosphorylation of the transcription factor CREB, and induction of the AP-1 complex following experimental brain injury J. Neurosci. 15 2030-2039
  • [3] Kim H. C.(1985)Autoradiographic characterization of N-methyl-D-aspartate-quisqualate, and kainate-sensitive glutamate binding sites J. Pharmac. Exp. Ther. 233 254-263
  • [4] Pennypacker K.(1985)Possible therapeutic applications of antagonists of excitatory amino acid neurotransmitter Clin. Sci. 68 113-122
  • [5] Feng Z.(1991)Proto-oncogene transcription factors and epilepsy Trends Pharmacol. Sci. 12 343-349
  • [6] Qi Q.(1993)Molecular bilogy of vertebrate learning: Is c-fos a new beginning? J. Neurosci. Res. 34 377-381
  • [7] Kong L. Y.(1996)The effect of dextromethorphan on kainic acid-induced seizures in the rat Neurotoxicology 17 375-386
  • [8] Iadarola M.(1997)Dextromethorphan blocks opioid peptide gene expression in the rat hippocampus induced by kainic acid Neuropeptides 31 105-112
  • [9] Hong J. S.(1994)Antiracetam: an overview of its pharmacodynamic and pharmacokinetic properties and a review of its therapeutic potential in senile cognitive disorders Drugs and Aging 3 257-273
  • [10] Dash P. K.(1993)Kainic acid induced changes in opioid peptides genes and AP-1 protein expression in the rat hippocampus J. Neurochem. 60 204-211
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