Tooth Repair and Regeneration

被引：56
作者：
Angelova Volponi A. [1 ]
Zaugg L.K. [1 ,2 ]
Neves V. [1 ]
Liu Y. [1 ]
Sharpe P.T. [1 ]
机构：
[1] Centre for Craniofacial and Regenerative Biology, Dental Institute, King’s College London, London
[2] Department of Periodontology, Endodontology and Cariology, University Center for Dental Medicine Basel, University of Basel, Basel
来源：
Current Oral Health Reports | 2018年 / 5卷 / 4期
关键词：
Bio-tooth; Biological repair; Dentinogenesis; Regenerative dentistry; Reparative dentin;
D O I：
10.1007/s40496-018-0196-9
中图分类号：
学科分类号：
摘要：
Purpose of Review: Current dental treatments are based on conservative approaches, using inorganic materials and appliances. This report explores and discusses the newest achievements in the field of “regenerative dentistry,” based on the concept of biological repair as an alternative to the current conservative approach. Recent Findings: The review covers and critically analyzes three main approaches of tooth repair: the re-mineralization of the enamel, the biological repair of dentin, and whole tooth engineering. Summary: The development of a concept of biological repair based on the role of the Wnt signaling pathway in reparative dentin formation offers a new translational approach into development of future clinical dental treatments. In the field of bio-tooth engineering, the current focus of the researchers remains the establishment of odontogenic cell-sources that would be viable and easily accessible for future bio-tooth engineering. © 2018, The Author(s).
引用
收藏
页码：295 / 303
页数：8
相关论文
共 76 条
  • [1] Righolt A.J., Jevdjevic M., Marcenes W., Listl S., Global-, regional-, and country-level economic impacts of dental diseases in 2015, J Dent Res, 97, 5, pp. 501-507, (2018)
  • [2] Kassebaum N.J., Bernabe E., Dahiya M., Bhandari B., Murray C.J., Marcenes W., Global burden of severe tooth loss: a systematic review and meta-analysis, J Dent Res, 93, 7, pp. 20-28, (2014)
  • [3] Kassebaum N.J., Smith A.G.C., Bernabe E., Fleming T.D., Reynolds A.E., Vos T., Et al., Global, regional, and national prevalence, incidence, and disability-adjusted life years for oral conditions for 195 countries, 1990-2015: a systematic analysis for the global burden of diseases, injuries, and risk factors, J Dent Res, 96, 4, pp. 380-387, (2017)
  • [4] Kassebaum N.J., Bernabe E., Dahiya M., Bhandari B., Murray C.J., Marcenes W., Global burden of untreated caries: a systematic review and metaregression, J Dent Res, 94, 5, pp. 650-658, (2015)
  • [5] Petersen P.E., The world oral health report 2003: continuous improvement of oral health in the 21st century—the approach of the WHO global oral health Programme, Community Dent Oral Epidemiol, 31, 1, pp. 3-23, (2003)
  • [6] Abraham C.M., A brief historical perspective on dental implants, their surface coatings and treatments, Open Dent J, 8, pp. 50-55, (2014)
  • [7] Hasan I., Heinemann F., Bourauel C., The relationship of bone resorption around dental implants to abutment design: a preliminary 1-year clinical study, Int J Prosthodont, 24, 5, pp. 457-459, (2011)
  • [8] Maiorana C., Sigurta D., Mirandola A., Garlini G., Santoro F., Bone resorption around dental implants placed in grafted sinuses: clinical and radiologic follow-up after up to 4 years, Int J Oral Maxillofac Implants, 20, 2, pp. 261-266, (2005)
  • [9] Nanci A., Ten Cate A.R., Ten Cate's Oral Histology: Development, Structure, and Function, (2003)
  • [10] ten Cate J.M., Review on fluoride, with special emphasis on calcium fluoride mechanisms in caries prevention, Eur J Oral Sci, 105, 5, pp. 461-465, (1997)
12345678