共 581 条
- [1] Sondergaard JN(2010)Differential sensitivity of melanoma cell lines with BRAFV600E mutation to the specific Raf inhibitor PLX4032 J Transl Med 8 39-599
- [2] Nazarian R(2010)Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma Nature 467 596-365
- [3] Wang Q(2012)Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial Lancet 380 358-714
- [4] Guo D(2012)Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib N Engl J Med 366 707-209
- [5] Hsueh T(2011)Acquired and intrinsic BRAF inhibitor resistance in BRAF V600E mutant melanoma Biochem Pharmacol 82 201-977
- [6] Mok S(2010)Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation Nature 468 973-390
- [7] Sazegar H(2012)Melanoma whole-exome sequencing identifies (V600E)B-RAF amplification-mediated acquired B-RAF inhibitor resistance Nat Commun 3 724-972
- [8] MacConaill LE(2011)RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E) Nature 480 387-3096
- [9] Barretina JG(2010)COT drives resistance to RAF inhibition through MAP kinase pathway reactivation Nature 468 968-20416
- [10] Kehoe SM(2011)Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling J Clin Oncol 29 3085-1703