Antiangiogenesis-Combined Photothermal Therapy in the Second Near-Infrared Window at Laser Powers Below the Skin Tolerance Threshold

被引：0
作者：
Jian-Li Chen
Han Zhang
Xue-Qin Huang
Hong-Ye Wan
Jie Li
Xing-Xing Fan
Kathy Qian Luo
Jinhua Wang
Xiao-Ming Zhu
Jianfang Wang
机构：
[1] Macau University of Science and Technology,State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health
[2] The Chinese University of Hong Kong,Department of Physics
[3] University of Macau,Faculty of Health Sciences
[4] Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing Key Laboratory of Drug Targets Research and New Drug Screening, Institute of Materia Medica
来源：
Nano-Micro Letters | 2019年 / 11卷
关键词：
Antiangiogenesis therapy; Core@shell nanostructures; Gold nanobipyramids; Photothermal therapy; Plasmon resonance;
D O I：
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中图分类号：
学科分类号：
摘要：
Titania-coated Au nanobipyramids (NBP@TiO2) with a high photothermal conversion efficiency in the NIR-II window are synthesized.The TiO2 shell is capable for the loading of the anticancer drug combretastatin A-4 phosphate (CA4P).The CA4P-loaded NBP@TiO2 nanostructures subjected with photothermal therapy induce synergistic anticancer and antiangiogenesis effects under 1064-nm laser irradiation at a power density lower than the skin tolerance threshold value.
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