Heterogeneity of release-inhibiting muscarinic autoreceptors in heart atria and urinary bladder: a study with M2- and M4-receptor-deficient mice

被引：0

作者：

Hongxia Zhou

Angelika Meyer

Klaus Starke

Jesus Gomeza

Jürgen Wess

Anne-Ulrike Trendelenburg

机构：

[1] Institut für Experimentelle und Klinische Pharmakologie und Toxikologie,

[2] Hermann-Herder-Strasse 5,undefined

[3] D-79104 Freiburg i.Br.,undefined

[4] Germany,undefined

[5] Laboratory of Bioorganic Chemistry,undefined

[6] NIH-NIDDK,undefined

[7] 8 Center Drive MSC 0810,undefined

[8] Bethesda,undefined

[9] MD 20892-0810,undefined

[10] USA,undefined

来源：

Naunyn-Schmiedeberg's Archives of Pharmacology | 2002年 / 365卷

关键词：

Parasympathetic neurons Acetylcholine release Autoreceptors Presynaptic receptors Muscarinic receptors M2-receptors M4-receptors Knockout mice;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Release-inhibiting muscarinic autoreceptors were studied in heart atria and the urinary bladder of NMRI mice, M2-receptor-deficient mice, M4-receptor-deficient mice, and wildtype mice sharing the genetic background of the knockout animals. Segments of the tissues were preincubated with 3H-choline and then superfused and stimulated electrically.

引用

页码：112 / 122

页数：10