Allergens/antigens, toxins and polyketides of important Aspergillus species

被引：21
作者：
Bhetariya P.J. [1 ]
Madan T. [2 ]
Basir S.F. [3 ]
Varma A. [1 ]
Usha S.P. [1 ]
机构：
[1] Division of Plant Pathology, Indian Agricultural Research Institute, Pusa
[2] National Institute for Research in Reproductive Health (NIRRH), Parel
[3] Department of Biosciences, Jamia Millia Islamia
来源：
Indian Journal of Clinical Biochemistry | 2011年 / 26卷 / 2期
关键词：
Allergens; Aspergillus species; Polyketides;
D O I：
10.1007/s12291-011-0131-5
中图分类号：
学科分类号：
摘要：
The medical, agricultural and biotechnological importance of the primitive eukaryotic microorganisms, the Fungi was recognized way back in 1920. Among various groups of fungi, the Aspergillus species are studied in great detail using advances in genomics and proteomics to unravel biological and molecular mechanisms in these fungi. Aspergillus fumigatus, Aspergillus flavus, Aspergillus niger, Aspergillus parasiticus, Aspergillus nidulans and Aspergillus terreus are some of the important species relevant to human, agricultural and biotechnological applications. The potential of Aspergillus species to produce highly diversified complex biomolecules such as multifunctional proteins (allergens, antigens, enzymes) and polyketides is fascinating and demands greater insight into the understanding of these fungal species for application to human health. Recently a regulator gene for secondary metabolites, LaeA has been identified. Gene mining based on LaeA has facilitated new metabolites with antimicrobial activity such as emericellamides and antitumor activity such as terrequinone A from A. nidulans. Immunoproteomic approach was reported for identification of few novel allergens for A. fumigatus. In this context, the review is focused on recent developments in allergens, antigens, structural and functional diversity of the polyketide synthases that produce polyketides of pharmaceutical and biological importance. Possible antifungal drug targets for development of effective antifungal drugs and new strategies for development of molecular diagnostics are considered. © Association of Clinical Biochemists of India 2011.
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页码：104 / 119
页数：15
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共 119 条
[1]  
Tillie-Leblond I., Tonnel A.-B., Allergic bronchopulmonary aspergillosis, Allergy: European Journal of Allergy and Clinical Immunology, 60, 8, pp. 1004-1013, (2005)
[2]  
Dagenais T.R., Keller N.P., Pathogenesis of Aspergillus fumigatus in invasive Aspergillosis, Clin Microbiol Rev, 22, 3, pp. 447-465, (2009)
[3]  
Bennett J.W., Aspergillus: A primer for the novice, Med Mycol, 47, SUPPL. 1, (2009)
[4]  
Karaffa L., Sandor E., Fekete E., Szentirmai A., The biochemistry of citric acid accumulation by Aspergillus niger (a review), Acta Microbiologica et Immunologica Hungarica, 48, 3-4, pp. 429-440, (2001)
[5]  
Barrios-Gonzalez J., Miranda R.U., Biotechnological production and applications of statins, Appl Microbiol Biotechnol, 85, 4, pp. 869-883, (2010)
[6]  
Cleveland T.E., Nierman W.C., Genomics of industrial Aspergilli and comparison with toxigenic relatives, Food Addit Contam A, 25, 9, pp. 1147-1151, (2008)
[7]  
Bhabhra R., Askew D.S., Thermotolerance and virulence of Aspergillus fumigatus: Role of the fungal nucleolus, Medical Mycology, 43, SUPPL.1, (2005)
[8]  
Chang Y.C., Tsai H.-F., Karos M., Kwon-Chung K.J., THTA, a thermotolerance gene of Aspergillus fumigatus, Fungal Genetics and Biology, 41, 9, pp. 888-896, (2004)
[9]  
Hohl T.M., Feldmesser M., Aspergillus fumigatus: Principles of pathogenesis and host defense, Eukaryotic Cell, 6, 11, pp. 1953-1963, (2007)
[10]  
Beauvais A., Monod M., Wyniger J., Debeaupuis J.P., Grouzmann E., Brakch N., Svab J., Hovanessian A.G., Latge J.P., Dipeptidyl-peptidase IV secreted by Aspergillus fumigatus, a fungus pathogenic to humans, Infection and Immunity, 65, 8, pp. 3042-3047, (1997)
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