Spectrum of low-density lipoprotein receptor (LDLR) mutations in a cohort of Sri Lankan patients with familial hypercholesterolemia – a preliminary report

被引:0
作者
C. S. Paththinige
J. R. D. K. Rajapakse
G. R. Constantine
K. P. Sem
R. R. Singaraja
R. W. Jayasekara
V. H. W. Dissanayake
机构
[1] University of Colombo,Human Genetics Unit, Faculty of Medicine
[2] Rajarata University of Sri Lanka,Faculty of Medicine and Allied Sciences
[3] University of Colombo,Department of Clinical Medicine, Faculty of Medicine
[4] National University of Singapore,Translational Laboratory in Genetic Medicine, Agency for Science Technology and Research
来源
Lipids in Health and Disease | / 17卷
关键词
Familial hypercholesterolemia; gene; Single nucleotide variants (SNV);
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 176 条
[1]  
Soutar AK(2007)Mechanisms of disease: genetic causes of familial hypercholesterolemia Nat Clin Pract Cardiovasc Med 4 214-225
[2]  
Naoumova RP(2008)Genetic heterogeneity of autosomal dominant hypercholesterolemia Clin Genet 73 1-3
[3]  
Varret M(1992)Molecular genetics of the LDL receptor gene in familial hypercholesterolemia Hum Mutat 1 445-466
[4]  
Abifadel M(2004)Genetic causes of monogenic heterozygous familial hypercholesterolemia: a HuGE prevalence review Am J Epidemiol 160 407-420
[5]  
Rabès JP(2000)Clinical expression of familial hypercholesterolemia in clusters of mutations of the LDL receptor gene that cause a receptor-defective or receptor-negative phenotype Arterioscler Thromb Vasc Biol 20 e41-e52
[6]  
Boileau C(2013)Spectrum of mutations and phenotypic expression in patients with autosomal dominant hypercholesterolemia identified in Italy Atherosclerosis 227 342-348
[7]  
Hobbs HH(2014)Presence and type of low density lipoprotein receptor (LDLR) mutation influences the lipid profile and response to lipid-lowering therapy in Brazilian patients with heterozygous familial hypercholesterolemia Atherosclerosis 233 206-210
[8]  
Brown MS(2005)Genetic and environmental factors affecting the response to statin therapy in patients with molecularly defined familial hypercholesterolaemia Pharmacogenet Genomics 15 219-225
[9]  
Goldstein JL(2005)Low-density lipoprotein receptor genotype and response to pravastatin in children with familial hypercholesterolemia Circulation 112 3168-3173
[10]  
Austin MA(2012)Low-density lipoprotein receptor gene familial hypercholesterolemia variant database: update and pathological assessment Ann Hum Genet 76 387-401