Nicotinic cholinergic regulation of olfactory bulb blood flow response in aged rats

被引：0
作者：
Sae Uchida
Jura Moriya
Daichi Morihara
Fusako Kagitani
机构：
[1] Tokyo Metropolitan Institute of Gerontology,Department of Autonomic Neuroscience
[2] Tokyo University of Agriculture and Technology,Division of Applied Biological Chemistry, Graduate School of Agriculture
[3] Tokyo University of Agriculture and Technology,Department of Applied Biological Science, Faculty of Agriculture
来源：
The Journal of Physiological Sciences | / 73卷
关键词：
Aging; Olfactory bulb; Cerebral blood flow; Olfactory nerve stimulation; Nicotinic acetylcholine receptors; Rats;
D O I：
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学科分类号：
摘要：
In our previous research, we had demonstrated the crucial role of neuronal nicotinic acetylcholine receptors (nAChRs) in potentiation of the olfactory bulb blood flow response to olfactory stimulation in adult rats. The present study examined the effects of nAChR activation on the olfactory bulb blood flow response in rats aged 24–27 months. We found that, under urethane anesthesia, unilateral olfactory nerve stimulation (300 μA, 20 Hz, 5 s) increased blood flow within the ipsilateral olfactory bulb, without changes in the systemic arterial pressure. The increase in blood flow was dependent upon the current and frequency of the stimulus. Intravenous administration of nicotine (30 μg/kg) had little effect on the olfactory bulb blood flow response to nerve stimulation at either 2 Hz or 20 Hz. These results suggest a reduction in nAChR-mediated potentiation of the olfactory bulb blood flow response in aged rats.
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