Li-cadherin is Inversely Correlated with Galectin-3 Expression in Gastric Cancer

被引：0
作者：
Wei-Guo Dong
Qiong-Fang Yu
Yu Xu
Li-Fang Fan
机构：
[1] Renmin Hospital of Wuhan University,Department of Gastroenterology
[2] Renmin Hospital of Wuhan University,Department of Otolaryngology
[3] Wuhan University,Head and Neck Surgery
来源：
Digestive Diseases and Sciences | 2008年 / 53卷
关键词：
Gastric cancer; Li-cadherin; Galectin-3; Immunohistochemistry; Semiquantitative polymerase chain reaction;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The aims of this study were to examine the expressions of Li-cadherin and Galectin-3 in gastric cancer, and the correlation between Li-cadherin and Galectin-3 in gastric cancer was also analyzed. The present study investigated the expression level of Li-cadherin and Galectin-3 by immunohistochemistry and semiquantitative polymerase chain reaction (PCR), and correlated this with clinicopathologic parameters in 91 cases of gastric cancer. The correlation between expression levels of Li-cadherin and Galectin-3 was analyzed by Spearman correlation analysis. The expression level of Li-cadherin mRNA was correlated to differentiation and lymph node metastasis, and the expression level of Galectin-3 was related to TNM staging, differentiation and lymph node metastasis. On Spearman correlation analysis, a definitive negative correlation was found between the expression levels of Li-cadherin and Galectin-3 in gastric cancerous tissues. We postulate that interaction between Li-cadherin and Galectin-3 may play an important role in the development of gastric cancer.
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页码：1811 / 1817
页数：6
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