Metformin action in human hepatocytes: coactivation of atypical protein kinase C alters 5′-AMP-activated protein kinase effects on lipogenic and gluconeogenic enzyme expression

[11] Myers R(2004)PKCλ in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity J Biol Chem 279 24929-1207

[12] Li Y(2009)Insulin-induced activation of atypical protein kinase C, but not protein kinase B, is maintained in diabetic (ob/ob and Goto-Kakazaki) liver. Contrasting insulin signaling patterns in liver versus muscle define phenotypes of type 2 diabetic and high-fat-induced insulin-resistant states Diabetologia 52 1197-1145

[13] Musi N(2009)Role of atypical protein kinase C in activation of sterol regulatory element binding protein-1c and nuclear factor kappa B (NFkappaB) in liver of rodents used as model of diabetes, and relationships to hyperlipidaemia and insulin resistance J Lipid Res 50 1133-1457

[14] Hirshman MF(2012)Critical role of atypical protein kinase C in activating hepatic SREBP-1c and NFκB in obesity Diabetologia 55 1446-149

[15] Nygren J(2004)Insulin signalling in hepatocytes of type 2 diabetic humans. Excessive expression and activity of PKC-ι and dependent processes and reversal by PKC-ι inhibitors Rev Endocr Metab Disord 5 143-216

[16] Shaw RJ(2007)New insights into the integrated physiology of insulin action Cell Metab 6 208-469

[17] Lamia KA(2012)Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor foxo 1 in liver Metabolism 61 459-8596

[18] Vasquez D(1999)Correction of metabolic abnormalities in a rodent model of obesity, metabolic syndrome and type 2 diabetes by inhibitors of hepatic protein kinase C-iota J Biol Chem 274 8589-1574

[19] Stephenne X(2008)Protein kinase Czeta is a negative regulator of protein kinase B activity Exp Cell Res 314 1566-14465

[20] Foretz M(2001)PI3K activates negative and positive signals to regulate TRB3 expression in hepatic cells J Biol Chem 276 14459-2521

[11] Myers R(2004)PKCλ in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity J Biol Chem 279 24929-1207

[12] Li Y(2009)Insulin-induced activation of atypical protein kinase C, but not protein kinase B, is maintained in diabetic (ob/ob and Goto-Kakazaki) liver. Contrasting insulin signaling patterns in liver versus muscle define phenotypes of type 2 diabetic and high-fat-induced insulin-resistant states Diabetologia 52 1197-1145

[13] Musi N(2009)Role of atypical protein kinase C in activation of sterol regulatory element binding protein-1c and nuclear factor kappa B (NFkappaB) in liver of rodents used as model of diabetes, and relationships to hyperlipidaemia and insulin resistance J Lipid Res 50 1133-1457

[14] Hirshman MF(2012)Critical role of atypical protein kinase C in activating hepatic SREBP-1c and NFκB in obesity Diabetologia 55 1446-149

[15] Nygren J(2004)Insulin signalling in hepatocytes of type 2 diabetic humans. Excessive expression and activity of PKC-ι and dependent processes and reversal by PKC-ι inhibitors Rev Endocr Metab Disord 5 143-216

[16] Shaw RJ(2007)New insights into the integrated physiology of insulin action Cell Metab 6 208-469

[17] Lamia KA(2012)Impaired regulation of hepatic glucose production in mice lacking the forkhead transcription factor foxo 1 in liver Metabolism 61 459-8596

[18] Vasquez D(1999)Correction of metabolic abnormalities in a rodent model of obesity, metabolic syndrome and type 2 diabetes by inhibitors of hepatic protein kinase C-iota J Biol Chem 274 8589-1574

[19] Stephenne X(2008)Protein kinase Czeta is a negative regulator of protein kinase B activity Exp Cell Res 314 1566-14465

[20] Foretz M(2001)PI3K activates negative and positive signals to regulate TRB3 expression in hepatic cells J Biol Chem 276 14459-2521