Metformin action in human hepatocytes: coactivation of atypical protein kinase C alters 5′-AMP-activated protein kinase effects on lipogenic and gluconeogenic enzyme expression

[1] Hundal RS(2000)Mechanism by which metformin reduces glucose production in type 2 diabetes Diabetes 49 2000-382

[2] Krssak M(2006)Metformin improves atypical protein kinase C activation by insulin and phosphatidylinositol-3,4,5-(PO Diabetologia 49 375-E192

[3] Dufour S(2010)) in diabetic muscle Am J Physiol Endocrinol Metab 298 E179-1174

[4] Luna V(2001)AICAR and metformin, but not exercise, increase muscle glucose transport through AMPK-, ERK- and PDK1-dependent activation of atypical PKC J Clin Invest 108 1167-2081

[5] Casauban L(2002)Role of AMP-activated protein kinase in mechanism of metformin action Diabetes 51 2074-1646

[6] Sajan MP(2005)Metformin increases AMP-activated protein kinase activity in skeletal muscle of subjects with type 2 diabetes Science 310 1642-3110

[7] Sajan MP(2011)The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin Diabetologia 54 3101-646

[8] Bandyopadhyay G(2009)Metformin activates AMP-activated kinase in primary human hepatocytes by decreasing cellular energy status Cell 15 635-23562

[9] Miura A(2002)Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding protein J Biol Chem 277 23554-944

[10] Zhou G(2003)Activation of the ERK pathway and atypical protein kinase C isoforms in exercise- and AICAR-stimulated glucose transport J Clin Invest 112 935-24934

[1] Hundal RS(2000)Mechanism by which metformin reduces glucose production in type 2 diabetes Diabetes 49 2000-382

[2] Krssak M(2006)Metformin improves atypical protein kinase C activation by insulin and phosphatidylinositol-3,4,5-(PO Diabetologia 49 375-E192

[3] Dufour S(2010)) in diabetic muscle Am J Physiol Endocrinol Metab 298 E179-1174

[4] Luna V(2001)AICAR and metformin, but not exercise, increase muscle glucose transport through AMPK-, ERK- and PDK1-dependent activation of atypical PKC J Clin Invest 108 1167-2081

[5] Casauban L(2002)Role of AMP-activated protein kinase in mechanism of metformin action Diabetes 51 2074-1646

[6] Sajan MP(2005)Metformin increases AMP-activated protein kinase activity in skeletal muscle of subjects with type 2 diabetes Science 310 1642-3110

[7] Sajan MP(2011)The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin Diabetologia 54 3101-646

[8] Bandyopadhyay G(2009)Metformin activates AMP-activated kinase in primary human hepatocytes by decreasing cellular energy status Cell 15 635-23562

[9] Miura A(2002)Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding protein J Biol Chem 277 23554-944

[10] Zhou G(2003)Activation of the ERK pathway and atypical protein kinase C isoforms in exercise- and AICAR-stimulated glucose transport J Clin Invest 112 935-24934