B cell non-Hodgkin’s lymphoma in chronic hepatitis C virus patients: An interesting relationship

被引：0
作者：
Hamdy H.S. [1 ]
Abdelkader N.A. [1 ]
Mansour A. [2 ]
Allam E.H. [1 ]
El-Wakiel H.M. [3 ]
Elshenawy D. [4 ]
机构：
[1] Department of Tropical Medicine, Ain Shams University, Alabbasiya, Cairo
[2] Department of Medical Biochemistry and Molecular Biology, Ain Shams University, Alabbasiya, Cairo
[3] Department of Clinical Oncology, Ain Shams University, Alabbasiya, Cairo
[4] Department of Clinical Pathology and Immunology, Ain Shams University, Alabbasiya, Cairo
来源：
Indian Journal of Gastroenterology | 2015年 / 34卷 / 2期
关键词：
BLyS; Cryoglobulinemia; Hepatitis C virus; NHL;
D O I：
10.1007/s12664-015-0549-4
中图分类号：
学科分类号：
摘要：
Background: An association exists between hepatitis C virus (HCV) infection and non-Hodgkin’s lymphoma (NHL), but a causal relationship is not fully established. HCV is a lymphotropic virus that represents a major etiologic agent of mixed cryoglobulinemia (MC) type II which is characterized by a low-grade B cell clonal lymphoproliferative disorder that usually progresses to a more aggressive malignant lymphoma. This study assessed the role of cryoglobulin and B lymphocyte stimulator (BLys) in the pathogenesis of NHL in chronic HCV patients. Methods: Sixty HCV patients, 30 free of B cell NHL (group I) and 30 with B cell NHL (group II), and 30 healthy controls (group III) were studied. Qualitative cryoglobulin assessment and a quantitative assay for BLys were done. Results: In group II, BLyS positivity rate was 1.5-fold higher than of group I (p ≤ 0.01). A positive association was found between positivity rate of MC and the level of BLyS (p ≤ 0.01). Conclusion: High BLyS levels were associated with HCV-associated lymphoproliferative disorder coupled with positive MC. © 2015, Indian Society of Gastroenterology.
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页码：127 / 134
页数：7
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